g-Secretase mediated ErbB4 Signaling Pathway
The HER4/erbB4 receptor tyrosine kinase is a member of the EGF1 receptor family. HER4 is a receptor for the neuregulins (NRGs), a family of growth and differentiation factors. HER4 can also bind and be activated by heparin-binding EGF growth factor, betacellulin, and epiregulin, members of the EGF family which, unlike the NRGs, are also ligands for the EGF receptor. HER4 mRNA is expressed in several tissues such as heart, brain, kidney, and skeletal muscle, suggesting that this receptor is involved in the development and maintenance of a variety of organs and cell types. It is likely that the control of expression and function of HER4 is important in normal development as well as in disease.
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REFERENCES: Ni, C.-Y., Murphy, M. P., Golde, T. E., Carpenter, G. (2001). gamma -Secretase Cleavage and Nuclear Localization of ErbB-4 Receptor Tyrosine Kinase. Science 294: 2179-2181 Rio C, Buxbaum JD, Peschon JJ, Corfas G. Tumor necrosis factor-alpha-converting enzyme is required for cleavage of erbB4/HER4. J Biol Chem 2000 Apr 7;275(14):10379-87
