WWP1基因编码的功能和结构描述
结构域蛋白广泛存在于真核生物中，在蛋白质降解、转录和rna剪接等多种细胞功能的调控中发挥着重要作用。该基因编码一个包含4个串联WW结构域和一个HECT（与E6相关蛋白羧基末端同源）结构域的蛋白质。编码的蛋白质属于NEDD4样蛋白家族，它是E3泛素连接酶分子，调节关键的转运决定，包括将蛋白质靶向蛋白质体或溶酶体该基因的选择性剪接产生至少6个转录变体；然而，这些转录的全长性质尚未确定。
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined.
