敏芯代谢组学平台介绍
上海敏芯科技，博士专家团队，11年服务经验，欢迎来电咨询。
上海敏芯信息科技有限公司成立于2006年10月，是国内知名的生物信息学服务提供商。随着业务扩展，公司已经发展成为国内较早专业提供系统生物学服务的高科技企业，提供包括基因组学、转录组学、蛋白质组学及代谢组学相关的实验设计、实验检测、数据分析、结果验证及论文修改的全面解决方案。公司已获得国家及上海市中小企业创新基金、上海市科技创新行动计划、上海市大学生创业基金、上海市专利试点企业、上海市技术成果转化认证、上海市杨浦区人才资助资金等多项国家及省部级奖励。
具体业务包括：
基因芯片：表达谱芯片、miRNA芯片、SNP芯片、甲基化芯片、Exon芯片、Tilling芯片、lncRNA芯片等实验及数据分析
高通量测序：miRNA测序、mRNA测序、基因组重测序、甲基化测序、ChIP-Seq等实验及数据分析
蛋白质组学：蛋白质芯片（SELDI）、细胞因子芯片、ITRAQ、Shotgun Proteomics、DIGE-2D等
代谢组学：液质联用（LC-MS）、气质联用（GC-MS）及核磁共振（NMR）的实验及数据分析
文献挖掘：提供基于pubmed数据库的关键词搜索服务
生物信息培训：定期举办综合性生物信息培训班，并提供上门培训服务及随到随学班
目前，公司国内外客户已超过1000家，合作发表了100多篇高影响因子的SCI(影响因子累计超过100分)，并参与多项国家科研项目的申请与实施。
提供的服务：
通过高通量分析技术（GC-MS,LC-MS,NMR等），分析处理组和正常组生物样本的代谢组物，通过采集图谱数据，利用统计分析方法寻找组间中具有差异性的代谢产物，并对其定性。
LC-MS : https://ibook.antpedia.com/7671/p/184742-p.html
GC-MS: https://ibook.antpedia.com/7671/p/184741-p.html
NMR: https://ibook.antpedia.com/7671/p/184743-p.html
实验阶段：
☆预实验阶段：对相关的实验条件（制备方法、仪器参数等）进行摸索，优化实验方法；
☆正式实验阶段：对样品进行实验操作，得到谱图；
数据分析阶段：
对实验得出的原始数据进行数据分析，分析服务包括：
本信息最终解释权归本公司所有
代谢组学文章：
海南医学院（GC-MS）
Man Xiao, Guankui Du, Guobing Zhong, et at. Gas Chromatography/Mass Spectrometry-Based Metabolomic Profiling Reveals Alterations in Mouse Plasma and Liver in Response to Fava Beans. PLoS ONE. 2016, 11(3): e0151103. doi:10.1371/journal.pone.0151103.
上海仁济医院&中山医院&上海中医药大学（LC-MS）
Xiang Chen, Chao Hu, Jican Dai, et at. Metabolomics Analysis of Seminal Plasma in Infertile Males with Kidney-Yang Deficiency: A Preliminary Study, eCAM. Volume 2015, Article ID 892930, 8 pages http://dx.doi.org/10.1155/2015/892930
北京林业大学（GC-MS）
Qiuming Wu, Min Chen, Hailong Zhou, et at. Metabolite profiles of Populus in response to pathogen stress. Biochemical and Biophysical Research Communications 465(2015) 421-426.
中国农科院&天津农学院（GC-MS）
Yunjun Liu, Gaoyi Cao, Guoying Wang, et at. Transgenic tobacco simultaneously overexpressing glyphosate N-acetyltransferase and 5-enolpyruvylshikimate- 3-phosphate synthase are more resistant to glyphosate than those containing one gene. Transgenic Res (2015) 24:753–763.
大连医科大学（LC-MS）
Lin Zhang, Meng Li, Libin Zhan, et at. Plasma Metabolomic Profiling of Patients with Diabetes-Associated Cognitive Decline, PLoS ONE. 2015, 10(5): e0126952. doi: 10.1371/journal. pone.0126952.
军事医学科学院（与基因组学整合分析）
Xulong Lang, Zhonghai Wan, Ying Pan, et at. Investigation into the role of catabolite control protein A in the metabolic regulation of Streptococcus suis serotype 2 using gene expression profile analysis, EXPERIMENTAL AND THERAPEUTIC MEDICINE 10: 127-132, 2015.
湖州中心医院（GC-MS& LC-MS）
Yingrong Chen, ZhihongMa, Lishan Min, et at. Biomarker Identification and Pathway Analysis by Serum Metabolomics of Lung Cancer, Hindawi Publishing Corporation BioMed Research International Volume 2015, Article ID 183624, 9 pages http://dx.doi.org/10.1155/2015/183624.
湖州中心医院（GC-MS& LC-MS）
Yingrong Chen, Zhihong Ma, Aiying Li, et at. Metabolomic profiling of human serum in lung cancer patients using liquid chromatography/hybrid quadrupole time-of-flight mass spectrometry and gas chromatography/mass spectrometry, J Cancer Res Clin Oncol, DOI 10.1007/****** 2014.
中山医院（LC-MS）
Fan Fan, Quan Cao, Cong Wang, et at. Impact of chronic low to moderate alcohol consumption on blood lipid and cardiac energy profile in acetaldehyde dehydrogenase 2-deficient mice, Acta Pharmacologica Sinica 2014: 1-8.
军事医学科学院（LC-MS）
Xulong Lang, Zhonghai Wan, Zhaoyang Bu, et at. Catabolite control protein A is an important regulator of metabolism in Streptococcus suis type 2, BIOMEDICAL REPORTS 2014, 2: 709-712.
云南师范大学（脂质组学）
Zhongguang Li, Huazong Zeng, Pingxing Ao, et at. Lipid response to short-term chilling shock and long-term chill hardening in Jatropha curcas L. seedlings, Acta Physiol Plant (2014) 36:2803–2814.
黑龙江八一农垦大学(NMR)
Sun LW, Zhang HY, Wu L, Shu S, Xia C, Xu C, Zheng JS. Hydrogen-1 nuclear magnetic resonance-based plasma metabolic profiling of dairy cows with clinical and subclinical ketosis, J. Dairy Sci. 2014, 97(3):1552-62(IF=2.65)
第四军医大学(NMR)
Lin Zhang, Yanglin Pan, Daiming Fan, et at. Distinguishing pancreatic cancer from chronic pancreatitis and healthy individuals by 1H nuclear magnetic resonance-based metabonomic profiles. Clinical Biochemistry 45(2012) 1064-1069.
黑龙江八一农垦大学(GC-MS)
Zhang H, Wu L, Xu C, Xia C, Sun L, Shu S. Plasma metabolomic profiling of dairy cows affected with ketosis using gas chromatography/mass spectrometry, BMC Veterinary Research,2013,9:186(IF=1.86)
中科院水生生物研究所(NMR)
He J, Chen J, Wu L, Li G, Xie P. Metabolic response to oral microcystin-LR exposure in the rat by NMR-based metabonomic study, J Proteome Res. 2012 Dec 7;11(12):5934-46, IF=5.46
复旦大学（GC-MS）
Ø Jiaoran Meng, Xiaodong Zhang, Hao Wu, et al., Morphine-induced conditioned place preference in mice: Metabolomic profiling of brain tissue to find “molecular switch” of drug abuse by gas chromatography/mass spectrometry, Analytica Chimica Acta. IF=4.309
深圳人民医院(NMR)
Ø X Ouyang, Y Dai ,et al, 1H NMR-based metabolomic study of metabolic profiling for systemic lupus erythematosu，lupus，2011 10 5. IF=2.6
中山医院(GC-MS)
Wu H, Xue R, Tang Z, Deng C, Liu T, Zeng H, Sun Y, Shen X , GC/MS-based metabolomic approach to validate the role of urinary sarcosine and target biomarkers for human prostate cancer by microwave-assisted derivatization, 2011 8;401(2):635-46. IF=3.78
中山医院(GC-MS)
Wu H, Xue R, Tang Z, Deng C, Liu T, Zeng H, Sun Y, Shen X , Metabolomic investigation of gastric cancer tissue using gas chromatography/mass spectrometry , Anal Bioanal Chem. 2010;396(4):1385-95. IF=3.328
中山医院(GC-MS)
Hao Wu, Ruyi Xue , Huazong Zeng, Xizhong Shen et al., Metabolomic profiling of human urine in hepatocellular carcinoma patients using gas chromatography/mass spectrometry, Analytica Chimica Acta,648 (2009) 98–104.IF=3.18
中山医院(GC-MS)
Hao Wu, Huazong Zeng, Xizhong Shen et al., Metabolomic study for diagnostic model of oesophageal cancer using gas chromatography/mass spectrometry, Journal of Chromatography B, 877 (2009) 3111–3117 .IF=2.935
浙江大学附属第一医院(LC-MS)
Feng Chen, Zhi Chen, et al., Identification of Serum Biomarkers of Hepatocarcinoma through Liquid?Chromatography/Mass Spectrometry-based Metabonomic Method, Anal Bioanal Chem2011 10;401(6):1899-904.IF=3.84
代谢组学技术服务价格
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