PI3K-AKT Signaling Pathway PCR Array

PI3K-AKT信号通路PCR基因芯片
 

Product	Species	Technology	Cat. No.
PI3K-AKT Signaling Pathway PCR Array	Human	Gene Expression	PAHS-058Z
PI3K-AKT Signaling Pathway PCR Array	Mouse	Gene Expression	PAMM-058Z
PI3K-AKT Signaling Pathway PCR Array	Rat	Gene Expression	PARN-058Z
PI3K-AKT Signaling Pathway PCR Array	Zebrafish	Gene Expression	PAZF-058Z

PI3K-AKT Signaling Pathway RT² Profiler™ PCR Array profiles the expression of 84 genes involved in PI3K-AKT signaling. This array contains members of the AKT (Protein Kinase B) and PI3K families and their regulators. Genes involved in several biological processes are represented including inactivation of Gsk3 and the accumulation of b-catenin, regulation of actin organization and cell migration, and BAD phosphorylation. Genes involved in the IGF-1, mTOR, and anti-apoptotic pathways are also contained in this array. Regulators of eIF4e and p70 S6 kinase activity are included as well. Using real-time PCR, you can easily and reliably analyze expression of a focused panel of genes related to PI3K-AKT signaling with this array.
PI3K-AKT信号通路PCR基因芯片可以同时检测与PI3K-AKT信号通路相关的84个基因的表达。芯片中包括AKT（蛋白激酶B）和PI3K家族成员及他们的调节基因，这些基因参与许多生物学过程：Gsk3失活、β-catenin的沉积、肌动蛋白的组装调控及细胞迁移、BAD磷酸化等。IGF-1、mTOR和抗凋亡信号通路相关的基因，调控elF4e和p70 S6激酶活性的基因也包含其中。利用实时定量PCR，研究者可以方便并且可信地对与PI3K-AKT信号通路相关的基因进行同时检测。
AKT and PI3K Family Members and Their Regulators:AKT1, AKT2, AKT3, BTK, GRB10, GRB2, HSPB1, ILK, MTCP1, PDK2, PDPK1, PIK3CA (p110a), PIK3CG, PIK3R1 (p85a), PIK3R2 (p85b), PAK1, PRKCA, PRKCB, PRKCZ, PTEN, TCL1A.
IGF-1 Signaling Pathway:CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF.
Inactivation of Gsk3 and the Accumulation of β-Catenin:ADAR, AKT1, APC, CCND1, CD14, CTNNB1, EIF2AK2, GJA1, GSK3B, IRAK1, MYD88, NFKB1, PDK1, TIRAP, TLR4, TOLLIP.
PI3K Subunit p85 Genes and Regulation of Actin Organization and Cell Migration:CDC42, PDGFRA, RAC1, RHOA, WASL.
PTEN Dependent Cell Cycle Arrest and Apoptosis:AKT1, CDKN1B (p27), FASLG, FOXO3, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK1, PDK2, PTEN, PTK2, RBL2, SHC1, SOS1.
BAD Phosphorylation and Anti-apoptotic Pathways:AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, RAF1, RPS6KA1, SHC1, SOS1, YWHAH.
Genes Involved in the mTOR Signaling Pathway:AKT1, EIF4B, EIF4E, EIF4EBP1, EIF4G1, FKBP1A, MTOR, PDK1, PDK2, PTEN, RHEB, RPS6KB1, TSC1, TSC2.
Regulation of eIF4e and p70 S6 Kinase:AKT1, EIF4E, EIF4EBP1 (4E-BP1), EIF4G1, MTOR, IRS1, MAPK1, MAPK14, MAPK3, PABPC1, PDK1, PDK2, PRKCA, PTEN, RPS6KB1.
Other Genes Involved in the AKT Signaling Pathway:CASP9, CHUK, FOXO1, NFKBIA