Polycomb & Trithorax Complexes EpiTect ChIP

qPCR Array 

Polycomb & Trithorax复合物ChIP qPCR芯片
 

Product	Species	Technology	Cat. No.
Polycomb & Trithorax Complexes EpiTect ChIP qPCR Array	Human	Histone Modifications	GH-506A
Polycomb & Trithorax Complexes EpiTect ChIP qPCR Array	Mouse	Histone Modifications	GM-506A

The Human Polycomb & Trithorax Complexes EpiTect Chip qPCR Array profiles the histone modification status or “histone code” of 84 genes encoding key polycomb and trithorax complex components including chromatin modification enzymes and remodeling factors. Histone modifications define chromatin structure, regulate gene activity and specify cellular status. The polycomb and trithorax complexes maintain epigenetic control of cell type specific gene expression patterns important for cellular identity via histone modification. The polycomb complex causes transcriptional repression, while the trithorax complex reverses that effect to maintain an active state of transcription. Dysregulation of these activities promotes oncogenesis by causing inappropriate expression of cell identity, differentiation and proliferation genes. Cancer research studies describe mutations in genes encoding polycomb and trithorax complex components, as well as complex regulators, during oncogenic transformation. Because these complexes play a central role in the epigenetic regulation of oncogenes and tumor suppressor genes, epigenetics may also stabilize their expression patterns, making an analysis of their own "histone code" also essential. This array includes core components of the polycomb and trithorax complexes as well as key interactors and genes necessary for complex assembly. Using chromatin immunoprecipitation and this real-time PCR Array, you can easily and reliably analyze the histone modification patterns associated with a focused gene panel involved in Polycomb and Trithorax complex activity.
The EpiTect Chip qPCR Arrays are intended for molecular biology applications. This product is not intended for the diagnosis, prevention, or treatment of a disease.
 
Polycomb & Trithorax复合物ChIP qPCR芯片分析编码Polycomb和Trithorax复杂组件包括染色质修饰酶和重构的因子的84个关键基因的组蛋白修饰状态或组蛋白密码。组蛋白修饰调节染色质结构和指定的细胞状态。Polycomb & Trithorax复合物通过组蛋白修饰参与表观遗传调控，是维持细胞特异性基因表达的重要机制。Polycomb复合体引起转录抑制；而Trithorax复合体行使反转效果，保持基因的积极转录。Polycomb & Trithorax复合物的活性控制着胚胎多能干细胞分化的机制的诱导。它们活性的失调造成细胞特性改变，细胞分化和增殖基因的错误表达，并促进肿瘤发生。癌症研究分析恶性转化过程编码polycomb trithorax复杂的组件,以及复杂的调节子基因发生突变。因为这些复合物对癌基因和肿瘤抑制基因的表观遗传调控发挥核心作用,表观遗传学也稳定它们的表达模式,所以对自己的“组蛋白密码”的分析是必要的。该芯片包括Polycomb & Trithorax复合物的核心组成基因和装配这些基因所必需的基因。利用这张芯片，通过实时定量PCR，可以简易且可靠地分析Polycomb & Trithorax复合物活动相关基因的表达。
 
miScript miRNA PCR芯片仅用于分子生物学应用。本产品不用于疾病的诊断、预防和治疗。
提供96孔板——384 -(4 x 96)板,和100孔板