为什么选择MS-Xelerator快速质谱数据系统？ 高速分析、性价比最高、用户体验友好 简单易学，对操作者无特殊要求 市场上速度最快的软件 非常快速、全面的质谱数据分析软件 同时适合LC-MS、GC-MS、CE-MS数据 图形化显示结果 快速强大的峰挑选算法和独特的过滤算法 代谢组学、定量蛋白质组学、杂质分析、差异分析 生物标记物发现的理想工具 |
| 蛋白质分离、纯度检测和定量分析 |
| 杂质轮廓（谱）分析 |
| 降解产物轮廓（谱）分析 |
| 代谢产物轮廓（谱）分析 |
| 差异分析 |
| 代谢组学 |
| 定量蛋白质组学 |
| 生物标记物发现 |
‘We successfully used the Reference Peak Warping (RPW) function of the MsXelerator software to align profiles of rat-urinary metabolites obtained by capillary electrophoresis–mass spectrometry. The excellent alignment allowed reliable principal component analysis revealing significant differences between antibiotic-treated and non-treated rats.’ Miranda de Kok, PhD, Biomedical Analysis, Dept. of Pharmaceutical Sciences, Faculty of Science University Utrecht, the Netherlands
“我们使用MsXelerator软件的RPW功能成功地校准了大鼠尿液代谢物的毛细管电泳-质谱数据。MsXelerator出色的校准功能保证了后续的主成分分析得以成功揭示抗生素治疗组和非治疗组大鼠尿液代谢物显著差异。” Miranda de Kok，博士，生物医学分析系，药学院，乌德勒支大学，荷兰‘We really enjoy working with MsMetrix to implement MsXelerator software according to our needs.? MsXelerator software, especially the part of the IPeaks module is a very powerful tool to process our routine reactive metabolite trapping data.’ Chenghong Zhang, Genentech (A Member of Roche), San Francisco, USA
“我们很乐意根据我们的需求使用MsMetrix公司的MsXelerator软件实施我们的工作。MsXelerator软件，尤其是IPeaks模块，是一个处理常规活性代谢物捕集数据的强大工具。” 张成洪，Genentech公司（罗氏公司的一员），旧金山，美国‘MsXelerator enabled us to select peptides from very complex mixtures by recognition of their specifically induced isotope pattern. Manual inspection of thousands of spectra has been replaced by an hour of analysis time using MsXelerator.’ Dr. P.A. van Veelen, LUMC, Head Mass Spectrometry Group, Leiden, the Netherlands
“通过MsXelerator，我们可以从非常复杂的混合肽中识别出具有特异诱导同位素模式的肽。应用MsXelerator分析 1小时就可以替代我们人工成千上万次的光谱检测工作。” P.A.van Veelen，博士，莱顿大学医学中心，质谱主席，莱顿，荷兰‘At Evolva SA, we have been using MsXelerator with great success for more than 4 years. Finding unknown molecules in complex sample matrix requires challenging and extensive LC/MS data mining, without mentioning the time needed to review high throughput screening data. MsXelerator software and particularly the module MPeaks does a great job in deconvoluting and comparing MS chromatograms in order to find the small differences which are relevant for our applications. Moreover, the clever interactivity between MPeaks and MS-compare help us accelerating our analysis thanks to the multiple filters and statistical tools, all with great confidence. Beyond all doubt, MsXelerator is a powerful all-in-one software platform to process LC/MS data, removing the hassle of buying several expensive add-ons from the instrument vendors. I also particularly enjoy the collaboration, expertise and quick responsiveness of MsMetrix, regarding customization to our special requests! ’ Christophe Folly, Research Scientist, Evolva SA, Switzerland
“在Evolva SA公司，4年前我们已开始使用MsXelerator，至今已经获得了巨大的成功。在复杂的样品中寻找未知的分子，需要面临的挑战是深度的LC / MS数据挖掘以及高通量的数据筛选所需要的时间。MsXelerator 软件特定的MPeaks模块在解卷积和比对质谱数据以及找寻和我们应用相关的最小差异方面做得很好。此外，MPeaks 和MS-compare灵活的交互性帮助我们加速分析速度，其多重过滤和统计分析工具给了我们巨大的信心。毫无疑问，对于处理LC / MS数据，MsXelerator是一个集强大功能于一身的软件平台。除了几个昂贵的组件需要从仪器供应商购买比较麻烦之外，我还特别欣赏MsMetrix公司的协作力、专业性以及对于我们特殊需求的快速响应力。” Christophe Folly，研究员，Evolva SA公司，瑞士‘MsXelerator is a real time-saver when processing our discovery and (pre)clinical Met-ID experiments at MSD (Schering-Plough, Organon).’ One workflow in a multi vendor ms lab. Searches for artificial isotope patterns at low level that worked (labeled compounds). Customization. Peter Jacobs, Head ADME Analysis, Schering-Plough
“在处理药物发现和临床Met-ID研究的质谱实验数据时，MsXelerator可以真正为我们节省时间（Schering-Plough公司，Organon）。” ·在多个供应商的MS实验室实现一个工作流程 ·搜索工作在较低水平的人造同位素模式（标记化合物） ·定制 Peter Jacobs，药物动力学分析主席，Schering-Plough‘MsXelerator is an essential tool nowadays in processing our proteomics datasets. It provides sensitive algorithms to search for mass spectral doublets, either targeting absolute mass differences (in the context of e.g. SILAC-based proteomics experiments or chemical modifications of amino acids) or relative mass differences. This latter feature is unique in its kind, as it allocates14N/15N-isotopically labeled peptides characterized by a relative mass difference of 1.2% of the m/z-value of the peptide and user-specified peak intensity ratios. For our Immuno Proteomics research we often apply 14N/15N-metabolic labeling protocols to target MHC-presented epitopes. MsXelerator is exceptional in allocating these typical mass spectral doublets, based on relative mass differences, charge states and intensity ratios. All data processing is performed on the raw MS data, without any prior data conversion. MsXelerator also supports high resolution MS data (e.g. Orbitrap datasets) that significantly reduces the false positive hits and speeds up the automated processing of our complex and large data sets. The flexibility of the user interface, allows us to set and define many search parameters, depending on the design of the experiment. MsXelerator also features a good built-in browser to view the raw data (chromatograms, extracted ion chromatograms, mass spectra) without switching back and forth to the MS-vendor originating data system. It is without any doubt that this application has boosted our Immuno Proteomics research. Moreover, the good hands-on training and the direct contact with the software developers of MsXelerator allows us to have user-defined modules integrated in the basic version of the application. ’ Hugo D. Meiring, PhD, Scientist Biomolecular Mass SpectrometryUnit Vaccinology, Centre for Infectious Disease Control Netherlands, National Institute for Public Health and the Environment.
“MsXelerator是我们目前处理蛋白质组学数据集的一个重要的工具。它提供了灵敏的算法来搜索质谱中的双峰，同时也适用于绝对质量差异（例如：基于SILAC的定量蛋白质组学实验或化学修饰的氨基酸）和相对质量差异。 后者的特点是独一无二的，其特点在于14N/15N同位素标记肽的分配，以m / z值的相对质量差为1.2％的肽和和用户指定的峰强度比为特征。我们在免疫蛋白质组学的研究中，通常采用14N/15N代谢标记目标MHC的抗原决定簇。根据相对质量差、电荷状态和强度比，MsXelerator在分配典型的质谱双峰时是很完美的。可对所有的原始MS数据进行处理，无需任何预处理。 MsXelerator还支持高分辨率质谱数据（例如：Orbitrap的数据集），显著地降低了假阳性出现，加快了自动处理复杂和庞大数据集的速度。用户界面灵活，允许我们根据实验的设计，设置并定义检索参数。 MsXelerator还拥有一个内置的浏览器用于直接查看原始数据（色谱图、离子色谱图、质谱），无需切换至质谱供应商提供的原始数据系统查看数据。 毫无疑问，这个应用程序提升了我们在免疫蛋白质组学上的研究。此外，良好的培训以及与MsXelerator软件开发人员的直接联系让我们可以在基础版本的基础上拥有用户自定义的集成模块。” Hugo D. Meiring，博士，分子生物学、单位疫苗学质谱方向的科学家，来自荷兰传染病控制中心国家公共卫生和环境研究所。