非常抱歉，我们暂时无法提供预览，您可以试试： 免费下载 ASTM D7427-08e2 前三页，或者稍后再访问。
您也可以尝试购买此标准，
点击右侧 “购买” 按钮开始采购（由第三方提供）。
点击下载后，生成下载文件时间比较长，请耐心等待......
5.1 IgE-mediated allergic reactions to protein allergens in natural rubber latex derived from the Hevea brasiliensis tree emerged in the 1990s as a concern with occasional allergic manifestations. Symptoms encompassing hives, uriticaria, rhinitis, asthma and anaphylaxis have all been reported in latex allergic individuals exposed to products derived from natural rubber latex.
5.2 Since no safe level of Hevea latex allergen exposure is known, avoidance is the primary mode of treating latex allergy.
5.3 As a result of investigations conducted by many scientists across the world, thirteen latex allergens have so far been identified and categorized by the Allergen Nomenclature Sub-Committee of the International Union of Immunological Societies (IUIS) as Hev b 1 to Hev b 13 (Table 1) (see Specification D1193). Reported sensitization rates for these allergenic Hev b proteins vary among the many reports as a result of differences in the study populations, IgE antibody assay methods and the quality of the Hev b allergens used as calibrators and quality control reagents in the analysis. Most studies, however, agree that Hev b 1 and Hev b 3 are important allergens for individuals (for example, children with spina bifida) who are exposed through mucosal contact as a result of multiple surgeries or latex catheter use for an extended period of time. Additionally, investigators performing sensitization studies also agree that Hev b 5 and Hev b 6.02 are important allergens that may elicit sensitization in genetically-predisposed individuals who are exposed to natural rubber latex (2-4). On the basis of these clinical studies, assays for these four allergenic proteins (that is, Hev b 1, Hev b 3, Hev b 5 and Hev b 6.02) have been developed and they are thus the subject of this standard. Adoption of immunoenzymetric assay reagents and standard proteins needed to quantify other latex allergens (other than Hev b 1, 3, 5, and 6.02) in extracts of natural rubber latex products will require separate documentation and validation.
| Name |
ASTM D7427-08e2相似标准
ASTM D7427-14 天然橡胶乳胶和气衍生产品中国四种主要致敏免疫蛋白 (Hev b 1, 3, 5和6.02) 测量的标准试验方法
ASTM D7427-08e1 天然橡胶及其胶乳衍生物中4种主要过敏蛋白质(Hev b 1, 3, 5和 6.02)免疫学测量的试验方法
ASTM D7427-16(2021) 四倍体天然橡胶及其产品衍生的四种主要过敏原蛋白（Hev b 1,3,5和6.02）的免疫测定标准检测方法
ASTM D7427-08 四倍体天然橡胶及其产品衍生的四种主要过敏原蛋白（Hev b 1,3,5和6.02）的免疫测定标准检测方法
ASTM D7427-16 四倍体天然橡胶及其产品衍生的四种主要过敏原蛋白（Hev b 1,3,5和6.02）的免疫测定标准检测方法
Copyright ©2007-2022 ANTPEDIA, All Rights Reserved |