2010年诺贝尔化学获奖论文精选

2010 Nobel Prize in Chemistry Awarded to Prolific ACS Authors

ACS Publications congratulates Richard F. Heck, Ei-ichi Negishi, and Akira Suzuki, who were jointly awarded the 2010 Nobel Prize in Chemistry "for palladium-catalyzed cross couplings in organic synthesis". The three Nobel Laureates have a combined total of more than 160 publications in ACS journals and books.

Please see below to:

    * Read comments from several ACS Editors
    * Enjoy free access to selected articles by the Nobel Laureates:
          o Richard F. Heck
          o Ei-ichi Negishi
          o Akira Suzuki
    * Link to search results listing all of the research they have published in ACS journals and books.

“Palladium-catalyzed cross coupling reactions are among the most important reactions for carbon-carbon bond formation and impact a broad spectrum of the chemical sciences from bioorganic, medicinal and materials chemistry to polymer and synthetic organic chemistry. This is a most deserved and appropriate Nobel Prize. I am very pleased that Professors Heck, Negishi and Suzuki published many of their seminal papers in this area in JACS.”
Peter J. Stang, Editor, Journal of the American Chemical Society
University of Utah

“The Editors of The Journal of Organic Chemistry congratulate Professors Richard F. Heck, Ei-ichi Negishi and Akira Suzuki on the occasion of their receiving the 2010 Nobel Prize in Chemistry and to express our thanks for their contributions to the Journal. We also wish to highlight the recent Perspective in the JOC [J. Org. Chem., 2010, 75 (10), pp 3151-3182] written by Professor Negeshi, which shows his beautiful cross coupling chemistry and developments from his laboratory.”
C. Dale Poulter , Editor-in-Chief, The Journal of Organic Chemistry
University of Utah

“In 2000 Negishi ‘showcased’ in elegant fashion the extraordinary power of the cross coupling reaction with his total synthesis of Xerulin [Org. Lett., 2000, 2, 65-67], an architecturally interesting inhibitor of cholesterol biosynthesis. This remarkable synthesis required a longest linear sequence of only 5-steps, and was achieved with an overall yield of 30% and greater than 96% stereoselectivity!”
Amos B. Smith III , Editor-in-Chief, Organic Letters
University of Pennsylvania

“The year 2010 Nobel Prize in chemistry honors three organometallic chemists who pioneered the use of palladium-based catalysts for carbon- carbon bond forming reactions. My own personal estimate of the number of papers published with the names Heck, Suzuki, and Negishi in the title or abstract would be 15,000 -- I look forward to learning the exact number (which could be easily determined by anyone with appropriate software), as perhaps this is way too low. Most of the work by the recipients was conducted in an era where the mechanistic understanding of organometallic chemistry was much more primitive than today. As such, it underscores the lasting importance of empiricism and fundamental research in science. Finally, one of the recipients had such a struggle for funding that he retired early, essentially giving up chemistry. This vividly illustrates the serious mistakes that sometimes occur in the course of well-intentioned peer review processes.”
John A. Gladysz , Editor-in-Chief, Organometallics
Texas A&M University

“Steve Buchwald guest-edited our Special Issue on Cross Coupling [Acc. Chem. Res., 2008, 41 (11), p 1439], one of the most active fields of organic chemistry, and a family of reactions that have revolutionized organic synthesis. The pioneering efforts by Heck, Ei-ichi Negishi (a contributor to this Special Issue), and Suzuki and many others who have contributed to Accounts have long been considered by organic chemists to be Nobel-worthy!””
Kendall N. Houk , Senior Editor, Accounts of Chemical Research
UCLA
Richard F. Heck

Palladium-Triarylphosphine Complexes as Catalysts for Vinylic Halide Reactions
Richard F. Heck
Advances in Chemistry, 1982, 196, Ch.12, pp 213-230.
DOI: 10.1021/ba-1982-0196.ch012

Palladium-catalyzed reactions of organic halides with olefins
Richard F. Heck
Acc. Chem. Res., 1979, 12(4), pp 146-151.
DOI: 10.1021/ar50136a006

Acylation, methylation, and carboxyalkylation of olefins by Group VIII metal derivatives
Richard F. Heck
J. Am. Chem. Soc., 1968, 90(20), pp 5518-5526.
DOI: 10.1021/ja01022a034

Palladium-catalyzed vinylic hydrogen substitution reactions with aryl, benzyl, and styryl halides
Richard F. Heck, and J. P. Nolley
J. Org. Chem., 1972, 37(14), pp 2320-2322.
DOI: 10.1021/jo00979a024

Palladium-catalyzed annulation of aryl iodides with diphenylacetylene
Guangzhong. Wu, Arnold L. Rheingold, Steven J. Geib, Richard F. Heck
Organometallics, 1987, 6(9), pp 1941-1946.
DOI: 10.1021/om00152a019

Ei-ichi Negishi

Controlled carbometalation as a new tool for carbon-carbon bond formation and its application to cyclization
Eiichi Negishi
Acc. Chem. Res., 1987, 20(2), pp 65-72.
DOI: 10.1021/ar00134a004

Palladium-Catalyzed Alkynylation
Ei-ichi Negishi and Luigi Anastasia
Chem. Rev., 2003, 103(5), pp 1979-2018.
DOI: 10.1021/cr020377i

An Efficient and Stereoselective Synthesis of Xerulin via Pd-Catalyzed Cross Coupling and Lactonization Featuring (E)-Iodobromoethylene as a Novel Two-Carbon Synthon
Ei-ichi Negishi, Asaf Alimardanov, and Caiding Xu
Org. Lett., 2000, 2(1), pp 65-67.
DOI: 10.1021/ol990336h

Palladium-catalyzed cross-coupling reaction of homoallylic or homopropargylic organozincs with alkenyl halides as a new selective route to 1,5-dienes and 1,5-enynes
Eiichi Negishi, Louis F. Valente, Makoto Kobayashi
J. Am. Chem. Soc., 1980, 102(9), pp 3298-3299.
DOI: 10.1021/ja00529a091

Alkyne Elementometalation-Pd-Catalyzed Cross-Coupling. Toward Synthesis of All Conceivable Types of Acyclic Alkenes in High Yields, Efficiently, Selectively, Economically, and Safely: “Green” Way
Ei-ichi Negishi, Guangwei Wang, Honghua Rao and Zhaoqing Xu
J. Org. Chem., 2010, 75(10), pp 3151-3182.
DOI: 10.1021/jo1003218

Palladium-Catalyzed Cross-Coupling Reactions with Zinc, Boron, and Indium Exhibiting High Turnover Numbers (TONs): Use of Bidentate Phosphines and Other Critical Factors in Achieving High TONs
Zhihong Huang, Mingxing Qian, David J. Babinski, and Ei-ichi Negishi
Organometallics, 2005, 24(4), pp 475-478.
DOI: 10.1021/om049106j

Akira Suzuki

Palladium-Catalyzed Cross-Coupling Reactions of Organoboron Compounds
Norio. Miyaura, Akira. Suzuki
Chem. Rev., 1995, 95(7), pp 2457-2483.
DOI: 10.1021/cr00039a007

Palladium-catalyzed inter- and intramolecular cross-coupling reactions of B-alkyl-9-borabicyclo[3.3.1]nonane derivatives with 1-halo-1-alkenes or haloarenes. Syntheses of functionalized alkenes, arenes, and cycloalkenes via a hydroboration-coupling sequence
Norio Miyaura, Tatsuo Ishiyama, Hirotomo Sasaki, Masako Ishikawa, Makoto Sato, Akira Suzuki
J. Am. Chem. Soc., 1989, 111(1), pp 314-321.
DOI: 10.1021/ja00183a048

Palladium-catalyzed cross-coupling reaction of organoboron compounds with organic triflates
Takayuki Ohe, Norio Miyaura, Akira Suzuki
J. Org. Chem., 1993, 58(8), pp 2201-2208.
DOI: 10.1021/jo00060a041