囊泡型谷氨酸转运蛋白1VGLUT1的研究进展丨艾美捷

囊泡谷氨酸转运体（VGLUTs）包括3个成员，VGLUT1、VGLUT2和VGLUT3。囊泡谷氨酸转运体（VGLUTs）的异常会导致兴奋性神经递质谷氨酸的异常，从而诱发多种神经系统疾病。

囊泡型谷氨酸转运蛋白1VGLUT1，又称BNPI和SLc17a7，zui初被鉴定为脑特异性磷酸转运蛋白。与相关的VGLUT-2一样，VGLUT-1对谷氨酸的摄取和储存既是必要的，也是充分的，因此构成了谷氨酸能表型的决定因素。这两种VGLUT都不同于血浆膜转运蛋白，因为它们是由跨囊泡膜的质子电化学梯度驱动的。

VGLUT 1和VGLUT 2呈现互补表达模式。总而言之，它们是目前谷氨酸能神经末梢和谷氨酸能突触的zui好标记物。

VGLUT 1 - 135 302，这个来自德国SySy的囊泡谷氨酸转运体1（抗体），特异性针对VGLUT1蛋白（经过敲除验证K.O），推荐作为谷氨酸能神经末梢的标记物。（使用说明：VGLUT 1在煮沸后聚集，因此建议对未煮沸的样品进行SDS-PAGE分析。）

发表文章超100+：Nature, Cell，课代表~

WB（23+）：

Vesicular Glutamate Transporters (SLCA17 A6, 7, 8) Control Synaptic Phosphate Levels.

Cheret C, Ganzella M, Preobraschenski J, Jahn R, Ahnert-Hilger G

Cell reports (2021) 342: 108623. 135 302 WB, ICC; tested species: human,mouse

IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α.

Tanabe Y, Naito Y, Vasuta C, Lee AK, Soumounou Y, Linhoff MW, Takahashi H

Nature communications (2017) 81: 408. 135 302 WB

IP（2+）：

Regulation of the Hippocampal Network by VGLUT3-Positive CCK- GABAergic Basket Cells.

Fasano C, Rocchetti J, Pietrajtis K, Zander JF, Manseau F, Sakae DY, Marcus-Sells M, Ramet L, Morel LJ, Carrel D, Dumas S, et al.

Frontiers in cellular neuroscience (2017) 11: 140. 135 302 WB, IP; tested species: mouse

ICC（33+）：

Neuronal defects in a human cellular model of 22q11.2 deletion syndrome.

Khan TA, Revah O, Gordon A, Yoon SJ, Krawisz AK, Goold C, Sun Y, Kim CH, Tian Y, Li MY, Schaepe JM, et al.

Nature medicine (2020) : . 135 302 ICC; tested species: human

Direct pericyte-to-neuron reprogramming via unfolding of a neural stem cell-like program.

Karow M, Camp JG, Falk S, Gerber T, Pataskar A, Gac-Santel M, Kageyama J, Brazovskaja A, Garding A, Fan W, Riedemann T, et al.

Nature neuroscience (2018) : . 135 302 ICC; tested species: human

IHC（40+）：

Context-Specific Striatal Astrocyte Molecular Responses Are Phenotypically Exploitable.

Yu X, Nagai J, Marti-Solano M, Soto JS, Coppola G, Babu MM, Khakh BS

Neuron (2020) : . 135 302 IHC; tested species: mouse

Hyperactivity with Disrupted Attention by Activation of an Astrocyte Synaptogenic Cue.

Nagai J, Rajbhandari AK, Gangwani MR, Hachisuka A, Coppola G, Masmanidis SC, Fanselow MS, Khakh BS

Cell (2019) : . 135 302 IHC; tested species: mouse

Other（1+）：

Transplantation of neurons derived from human iPS cells cultured on collagen matrix into guinea-pig cochleae.

Ishikawa M, Ohnishi H, Skerleva D, Sakamoto T, Yamamoto N, Hotta A, Ito J, Nakagawa T

Journal of tissue engineering and regenerative medicine (2017) 116: 1766-1778. 135 302

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