癌基因蛋白的概念定义与信息分析

　　Oncogene Protein gp140(v-fms)\\癌基因蛋白质gp140(v-fms)

　　Transforming glycoprotein coded by the fms oncogene from the Susan McDonough strain of feline sarcoma virus (SM-FeSV). The oncogene protein v-fms lacks sequences, which, in the highly homologous proto-oncogene protein c-fms (CSF-1 receptor), normally serve to regulate its tyrosine kinase activity. The missing sequences in v-fms mimic the effect of ligand and lead to constitutive cell growth. The protein gp120(v-fms) is post-translationally modified to generate gp140(v-fms).

　　由来自猫肉瘤病毒Susan McDonough毒株fms癌基因编码的转化糖蛋白。癌基因蛋白v-fms缺乏在高同源性原癌基因c-fms (CSF-1受体)内正常用于调节酪氨酸激酶活性的序列。在v-fms内缺乏的序列模拟配体的作用并引起固有性细胞生长。蛋白质gp120(v-fms)是翻译后修改产生gp140(v-fms)。

　　Oncogene Protein p21(ras)\\癌基因蛋白质p21(ras)

　　Transforming protein encoded by ras oncogenes. Point mutations in the cellular ras gene (c-ras) can also result in

　　a mutant p21 protein that can transform. mammalian cells. Oncogene protein p21(ras) has been directly implicated in human neoplasms, perhaps accounting for as much as 15-20% of all human tumors. This enzyme was formerly listed as EC 3.6.1.47.

　　由ras癌基因编码的转化蛋白。细胞ras基因(c-ras)的点突变也能产生一个可转化哺乳动物细胞的突变p21蛋白。癌基因蛋白质p21(ras)与人类肿瘤有直接关联，可能所有人类肿瘤的15-20%与之有关。该酶以前列为EC 3.6.1.47。

　　Oncogene Protein p55(v-myc)\\癌基因蛋白质p55(v-myc)

　　Transforming protein coded by myc oncogenes. The v-myc protein has been found in several replication-defective avian retrovirus isolates which induce a broad spectrum of malignancies.

　　由myc癌基因编码的转化蛋白。v-myc蛋白存在于可诱导广泛恶性肿瘤的几种复制缺陷性鸟类反转录病毒隔离群中。

　　Oncogene Protein p65(gag-jun)\\癌基因蛋白质p65(gag-jun)

　　Transforming protein coded by jun oncogenes (GENES, JUN). This is a gag-onc fusion protein of about 65 kDa derived from avian sarcoma virus. v-jun lacks a negative regulatory domain that regulates transcription in c-jun.

　　由jun癌基因(基因, JUN)编码的转化蛋白。这是一种大约65KDa来源于鸟类肉瘤病毒的gag-onc融合蛋白标记物。v-jun缺乏可调节c-jun转录的负调节区。

　　Oncogene Protein pp60(v-src)\\癌基因蛋白质pp60(v-src)

　　A tyrosine-specific protein kinase encoded by the v-src oncogene of Rous sarcoma virus. The transforming activity of pp60(v-src) depends on both the lack of a critical carboxy-terminal tyrosine phosphorylation site at position 527, and the attachment of pp60(v-src) to the plasma membrane which is accomplished by myristylation of its N-terminal glycine.

　　一种由Rous肉瘤病毒v-src癌基因编码的酪氨酸特异性蛋白激酶。pp60(v-src)的转化活性既由于在527位置缺乏一个决定性羧端酪氨酸磷酸化位点又由于pp60(v-src)附着到由其氨基末端甘氨酸十四烷基化形成的质膜上。

　　Oncogene Proteins\\癌基因蛋白质类

　　Proteins coded by oncogenes. They include proteins resulting from the fusion of an oncogene and another gene (ONCOGENE PROTEINS, FUSION).

　　由癌基因编码的蛋白质类。包括因癌基因与另一个基因融合形成的蛋白质(癌基因蛋白质类, 融合)。

　　Oncogene Proteins v-abl\\癌基因蛋白质v-abl

　　Transforming proteins encoded by the abl oncogenes. Oncogenic transformation of c-abl to v-abl occurs by insertional activation that results in deletions of specific N-terminal amino acids.

　　由abl癌基因编码的转化蛋白。c-abl到v-abl的致癌性转化由于插入激活而发生并引起特异性氨基末端氨基酸删除。

　　Oncogene Proteins v-erbA\\癌基因蛋白质v-erbA

　　Transforming proteins encoded by erbA oncogenes from the avian erythroblastosis virus. They are truncated versions of c-erbA, the thyroid hormone receptor (RECEPTORS, THYROID HORMONE) that have retained both the DNA-binding and hormone-binding domains. Mutations in the hormone-binding domains abolish the transcriptional activation function. v-erbA acts as a dominant repressor of c-erbA, inducing transformation by disinhibiting proliferation.

　　由来自禽幼红细胞增多症病毒erbA癌基因编码的转化蛋白。是保留DNA结合和激素结合区域的c-erbA甲状腺激素受体(受体, 甲状腺激素)的截断倒位。激素结合区的突变停止了转录激活功能。v-erbA作为c-erbA显性受体发挥作用，通过不限制增殖诱导转化。

　　Oncogene Proteins v-erbB\\癌基因蛋白质v-erbB

　　Transforming proteins encoded by erbB oncogenes from the avian erythroblastosis virus. The protein is a truncated form. of the EGF receptor (RECEPTOR, EPIDERMAL GROWTH FACTOR) whose kinase domain is constitutively activated by deletion of the ligand-binding domain.

　　由来自禽幼红细胞增多症病毒erbB癌基因编码的转化蛋白。该蛋白是其激酶区由于配体结合区删除组成性激活的EGF受体(受体, 表皮生长因子)的截断型。

　　Oncogene Proteins v-fos\\癌基因蛋白质v-fos

　　Transforming proteins coded by fos oncogenes. These proteins have been found in the Finkel-Biskis-Jinkins (FBJ-MSV) and Finkel-Biskis-Reilly (FBR-MSV) murine sarcoma viruses which induce osteogenic sarcomas in mice. The FBJ-MSV v-fos gene encodes a p55-kDa protein and the FBR-MSV v-fos gene encodes a p75-kDa fusion protein.

　　由fos癌基因编码的转化蛋白。这些蛋白存在于可诱导鼠骨肉瘤的Finkel-Biskis-Jinkins(FBJ-MSV)和Finkel-Biskis-Reilly(FBR-MSV)鼠肉瘤病毒中。FBJ-MSV v-fos基因编码p55-kDa蛋白，FBR-MSV v-fos基因编码p75-kDa融合蛋白。

　　Oncogene Proteins v-mos\\癌基因蛋白质v-mos

　　Transforming proteins coded by mos oncogenes. The v-mos proteins were originally isolated from the Moloney murine sarcoma virus (Mo-MSV).

　　由mos癌基因编码的转化蛋白。v-mos蛋白最初是从Moloney小鼠肉瘤病毒(Mo-MSV)中分离出来的。

　　Oncogene Proteins v-myb\\癌基因蛋白质v-myb

　　Transforming proteins coded by myb oncogenes. Transformation of cells by v-myb in conjunction with v-ets is seen in the avian E26 leukemia virus.

　　由myb癌基因编码的转化蛋白。通过与v-ets连接的v-myb的细胞转化可见于鸟类E26白血病病毒。

　　Oncogene Proteins v-raf\\癌基因蛋白质v-raf

　　A family of transforming proteins isolated from retroviruses such as MOUSE SARCOMA VIRUSES. They are viral-derived members of the raf-kinase family of serine-theonine kinases.

　　一类从反转录病毒如小鼠肉瘤病毒中分离出来的转化蛋白。它们是丝氨酸-苏氨酸激酶raf激酶家族的病毒衍生成员。

　　Oncogene Proteins v-rel\\癌基因蛋白质v-rel

　　Transforming proteins coded by rel oncogenes. The v-rel protein competes with rel-related proteins and probably transforms cells by acting as a dominant negative version of c-rel. This results in the induction of a broad range of leukemias and lymphomas.

　　由rel癌基因编码的转化蛋白。v-rel蛋白与rel相关蛋白竞争并很可能通过作为c-rel显性负相倒位起作用转化细胞。这引起广泛白血病和淋巴瘤的诱导发生。

　　Oncogene Proteins v-sis\\癌基因蛋白质v-sis

　　Transforming proteins coded by sis oncogenes. Transformation of cells by v-sis is related to its interaction with the PDGF receptor and also its ability to alter other transcription factors.

　　由sis癌基因编码的转化蛋白。通过v-sis的细胞转化与其与PDGF受体的相互作用有关并也与其改变其它转录因子的能力有关。

　　Oncogene Proteins, Fusion\\癌基因蛋白质类, 融合

　　The GENETIC TRANSLATION products of the fusion between an ONCOGENE and another gene. The latter may be of viral or cellular origin.

　　癌基因与另一个基因融合的遗传翻译产物。后者可能是病毒性或细胞源性。

　　Oncogene Proteins, Viral\\癌基因蛋白质类, 病毒性

　　Products of viral oncogenes, most commonly retroviral oncogenes. They usually have transforming and often protein kinase activities.

　　病毒癌基因最常为逆转录病毒致癌基因的产物。通常具有转化和蛋白激酶活性。

　　Oncogenes\\癌基因

　　Genes whose gain-of-function alterations lead to NEOPLASTIC CELL TRANSFORMATION. They include, for example, genes for activators or stimulators of CELL PROLIFERATION such as growth factors, growth factor receptors, protein kinases, signal transducers, nuclear phosphoproteins, and transcription factors. A prefix of "v-" before oncogene symbols indicates oncogenes captured and transmitted by RETROVIRUSES; the prefix "c-" before the gene symbol of an oncogene indicates it is the cellular homolog (PROTO-ONCOGENES) of a v-oncogene.

　　其功能获得改变导致肿瘤细胞转化的基因。包括控制细胞增殖催化剂或刺激物如生长因子、生长因子受体、蛋白激酶类、信号转导物、核磷蛋白类和转录因子的基因。癌基因符号前的前缀“v-”表明获得性及由反转录病毒传递的癌基因。癌基因基因符号前的前缀“c-”表明它是某个v-癌基因的细胞同系物。