科学家 Michael A Marletta （生物化学）

http://mcb.berkeley.edu/index.php?option=com_mcbfaculty&name=marlettam

Michael Marletta

Aldo DeBenedictis Distinguished Professor of Chemistry and Professor of Biochemistry and Molecular Biology

Lab Homepage: http://www.cchem.berkeley.edu/mmargrp/

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Research Interests

Research in this laboratory is focused on structure/function relationships in proteins with a particular emphasis on the catalytic and biological properties of enzymes and signaling proteins. Current emphasis is on nitric oxide signaling (including studies on nitric oxide synthase, guanylate cyclase and S-nitrosation mechanisms), oxygen sensing, pathogen responses to nitric oxide, and enzymology of biofuel utilization.

最新研究成果：

Carlson, H.K., Plate, L., Price, M.S., Allen, J.J., Shokat, K.M., and Marletta, M.A. (2010).  Use of a semisynthetic epitope to probe histidine Kinase activity and regulation.  Anal. Biochem. 397: 139-143.

Weinert, E.E., Plate, L., Whited, C.A., Olea, C. Jr, and Marletta, M.A. (2010). Determinants of ligand affinity and heme reactivity in H-NOX domains.  Angew. Chem. Int. Ed. Engl. 49: 720-723. 

Olea, C. Jr, Herzik, M.A. Jr, Kuriyan, J., and Marletta, M.A. (2010). Structural insights into the molecular mechanism of H-NOX activation.  Protein Science 19: 881-887. 

Woodward, J.J., Nejatyjahromy, Y., Britt, R.D., and Marletta, M.A.  (2010). Pterin-Centered Radical as a Mechanistic Probe of the Second Step of Nitric Oxide Synthase. J. Amer. Chem. Soc. 132: 5105-5113.

Wang, Y., Dufour, Y.S., Carlson, H.K., Donohue, T.J., Marletta, M.A., and Ruby, E.G. (2010). H-NOX-mediated NO sensing modulates symbiotic colonization byVibrio fischeri.  Proc. Natl. Acad. Sci. USA 107: 8375-8380.

Derbyshire, E.R., Fernhoff, N.B., Deng, S. and Marletta, M. A. (2009). Nucleotide regulation of soluble guanylate cyclase substrate specificity.  Biochemistry 48: 7519-7524.

Agapie, T., Suseno, S., Woodward, J.J., Stoll, S., Britt, R.D., and Marletta, M.A. (2009). NO Formation by a Protein from Sorangium cellulosum: A Catalytically Self-Sufficient Bacterial Nitric Oxide Synthase.  Proc. Natl. Acad. Sci. USA 106: 16221-16226. 

Fernhoff, N.B., Derbyshire, E.R. and Marletta, M.A. (2009). A nitric oxide/cysteine interaction mediates the activation of soluble guanylate cyclase.  Proc. Natl. Acad. Sci. USA 106: 21602-22607.

Erbil, W.K., Price, M.S., Wemmer, D.E., and Marletta, M.A. (2009). A structural basis for N-NOX signaling in Shewanella oneidensis by trapping a histidine kinase inhibitory conformation.  Proc. Natl. Acad. Sci. USA 106: 19753-19760. 

Tian, C., Beeson, W.T., Iavarone, A.T., Sun, J., Marletta, M.A., Cate, J.H., and Glass, N.L. (2009).  Systems analysis of plant cell wall degradation by the model filamentous fungus Neurospora crassa.  Proc. Natl. Acad. Sci. USA. 106: 22157-22162.

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