Hydrogen-Related Enhancement of In Vivo Antioxidant Ability in the Brain of Rats Fed Coral Calcium Hydride
Abstract
This
study explored the effect of coral calcium hydride (CCH) on rat
intrahippocampal antioxidant ability by measuring the PCAM nitroxide
radical decay ratio when CCH was (a) co-perfused into the hippocampus
and (b) fed orally to the rats for 4 weeks under a freely moving state.
Estimation of the in vivo antioxidant effect was obtained by
administration of the blood–brain barrier-permeable PCAM nitroxide
radical and the measured PCAM radical decay ratio then correlated to the
amount of antioxidant in the brain using electron spin resonance (ESR)
spectroscopy combined with microdialysis. The half-life periods of PCAM
in rats treated with CCH in both the co-perfusion and orally fed groups
were significantly shorter compared to the control group. These results
clarify the mechanism that CCH may exert antioxidant activity by
significantly enhancing the basal endogenous antioxidant ability in the
hippocampus through a synergistic effect with α-tocopherol and ascorbic
acid.
Keywords Hydrogen gas - Antioxidant effect - Hippocampus - Rat - Microdialysis
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