首页 行业 移动快检 食品 环境 先进材料 化工 生命科学 制药 临床 导购 安特百货 仪器谱 Webinar 前沿Lab 博客 会展 百科人才 搜索
上海中药创新研究中心

上海中药创新研究中心

      上海中药创新研究中心(以下简称“中心”)是在中国科技部和上海市人民政府的支持下,于 2000 年 4 月由上海市科委、上海市浦东新区政府和上海市张江高科技园区开发公司共同投资组建的中药现代化研究和开发机构,是国家中药现代化(上海)创新中心的依托单位,是国家生物医药基地重点建设的国家级专业孵化器之一,也是国家国际科技合作基地和上海市研究生联合培养基地。

      Shanghai Innovative Research Center of Traditional Chinese Medicine (SIRC/TCM), as a research and development (R&D) institution for TCM modernization, was co-founded by Science and Technology Committee of Shanghai, Pudong New Area Government of Shanghai and Shanghai Zhangjiang Hi-Tech Park Development Corporation in April 2000. With supports from Ministry of Science and Technology of China and Shanghai Municipal Government, SIRC/TCM is designated as a core Innovation Center of TCM Modernization in Shanghai, a national key incubator for biomedical research in China, an international science and technology cooperation base in China, and a post-graduation co-education base in Shanghai.

 

      作为国家级专业科研机构,中心以“市场为导向,创新为手段”,遵循“源于中药、高于中药”的研发理念,开创性地进行中药新药的探索研究,并独立创建了中药现代化的两大创新研究体系:

1)世界一流的大型综合性关联型中药数据库;

2)吸收/代谢后单体组合药物(PAMD)创新理念及其实验方法。

      中药数据库囊括了三万多个中草药中天然含有的活性化合物及其他信息,涉及分子结构、生物活性、化合物来源(草药)、毒性、中药方剂以及临床应用等。中药数据库已广泛应用于筛选先导化合物、研究中药作用机理、预见草药方剂毒性以及开发全新中药复方等。

      As a national R&D center, SIRC/TCM is innovation-oriented and market-guided with the mission of developing novel drugs that are “from TCM, better than TCM”. Our approach of TCM modernization is based on two innovations generated by SIRC scientists: 1) a world-class comprehensive and interactive TCM database; 2) a novel concept of Post-Absorption and Metabolism Drugs (PAMD). The TCM database contains information about more than 30,000 compounds that are active ingredients of TCM herbs. The interactive structure of this database provides information of these compounds in a range of molecular structure, biological activity, herbs containing those compounds, toxicity, as well as TCM formula and their clinical application. The database has been widely used in screening for lead compounds, studying mechanisms of TCM drugs, predicting toxicity of herbal combinations, as well as creating new TCM formulas.

 

      PAMD研究理念旨在从口服草药后存留于体内的化合物中探寻新药,而且这些草药的临床疗效确切,安全性稳定、可靠。因为人体吸收的化合物数量不足中药方剂所含化合物的1%,而且其中大量化合物是原有活性成分的代谢物,所以运用PAMD策略可以极大地提高从中药中探索先导化合物的效率,以研发新的单体化合物药物以及来自中药复方的组合化合物药物。中心已经成功研发了一系列拥有自主知识产权的新药,其中多个新药即将进入临床研究甚至已经上市。

      The concept of PAMD is to seek drug candidates among compounds existing in our body after orally taking TCM herbs, of which are with proven clinical benefits and demonstrated safety profiles. Given the fact that compounds absorbed by our body is less than 1% of those contained in TCM formula and many of them are metabolites of original active ingredients, PAMD strategy drastically improved efficiency in finding lead compounds from TCM for development of new single compound drugs as well as compound-combinations derived from TCM formulas. With the PAMD strategy, a series of proprietary drug candidates and products have been developed and some of them are near clinical stage or already on the market.

      中心的研发技术平台融合中药数据库、植物化学、分析技术、有机合成、分子药理学、细胞生物学、毒理、中药基因组、转录组学、代谢组学、药效动力学、计算机辅助药物设计、公斤级化学合成等多个学科。我们与国内外科学家和制药厂商保持广泛密切的联系和合作。我们深信,中药作为中国几千年临床应用实践证明了的无价瑰宝,若能融合创新研发理念和先进实验技术,那么古老而神秘的中药必将引入现代医学殿堂,为现代药物研发带来划时代的变革。

      Research at SIRC/TCM employs a broad technological platform that integrates TCM informatics, phytochemistry, analytical technology, organic synthesis, molecular pharmacology, cell biology, toxicology, TCM genomics, transcriptomics, metabolomics, pharmacokinetics, computer-aid drug design and kilogram-scale chemical synthesis. We are well-connected with national and international scientists and pharmaceutical industries. People at SIRC/TCM believe that TCM is priceless treasure generated by Chinese people through clinical practice in past thousands of years and that innovative concepts with integrative technologies will eventually bring the ancient TCM to the modern medical sciences and revolutionize our approach in drug discovery as well as development of the modern pharmaceutical industry.