Human Pain: Neuropathic & Inflammatory miScript miRNAs PCR Array: MIHS-120Z The Human Pain miScript miRNA PCR Array profiles the expression of 84 miRNAs involved in the transduction, maintenance, and modulation of pain responses. Noxious environmental stimuli, tissue damage, and disease all evoke pain. Since it afflicts up to 20% of the population at any given time, pain provides both a massive therapeutic target and a route to understanding the molecular mechanisms of nervous system function. While neuropathic pain often results from damage to the peripheral (PNS) or central nervous system (CNS), peripheral tissue damage and/or inflammation generally initiates inflammatory pain. Neuropathic and inflammatory pain both cause activation of damage-sensing neurons (nociceptors) that innervate the skin, muscle and viscera and terminate in the laminae of the spinal cord dorsal horn. Transduction of pain signals requires the expression of specific proteins such as ion channels and neurotransmitter receptors. Because miRNAs should regulate genes encoding components of molecular pain pathways, researchers have hypothesized that they may be critically important master switches modulating pain. To better understand their importance and role in regulating nociception and pain circuitries, several miRNAs profiling experiments have demonstrated differential miRNA expression in rodent pain models such as contusive spinal cord injury, inflammatory muscle pain, and ischemia-reperfusion injury. The differential expression of miRNA in blood from patients with complex regional pain syndrome suggests that miRNA may also prove to be valuable biomarkers of pain. The differentially expressed miRNAs in these studied have also been shown and/or predicted to regulate genes involved in pain molecular mechanisms such as apoptosis and inflammation. This array analyzes the expression of miRNA found in be differentially expressed in typical models of pain. A set of controls present on each array enables data analysis using the ΔΔCT method of relative quantification, assessment of reverse transcription performance, and assessment of PCR performance. Using SYBR Green real-time PCR, the expression of a focused panel of pain-related miRNAs can be easily and reliably analyzed with this miScript miRNA PCR Array.
96-well, 384-well ( 4 x 96 ), and Rotor-Disc 100 formats are available.    

Upregulated by Pain:
Upregulated by Contusive Spinal Cord Injury: miR-1, miR-145-5p, miR-146a-5p, miR-146b-5p, miR-152-3p, miR-15b-5p, miR-17-5p, miR-199a-3p, miR-203a, miR-206, miR-20a-5p, miR-20b-5p, miR-214-3p, miR-21-5p, miR-223-3p, miR-30a-3p, miR-31-5p, miR-374b-5p, miR-378a-3p, miR-92a-3p, miR-92b-3p, miR-98-5p.
Upregulated by Ischemia-Reperfusion Injury: miR-132-5p, miR-133a-3p, miR-204-3p, miR-323a-3p, miR-365b-3p, miR-369-5p, miR-376b-5p, miR-505-5p, miR-665.
Downregulated by Pain:
Downregulated by Contusive Spinal Cord Injury: miR-129-2-3p, miR-137, miR-138-5p, miR-219a-2-3p, miR-219a-5p, miR-30b-5p, miR-30c-5p, miR-30d-5p, miR-323a-3p, miR-338-5p, miR-34a-5p, miR-379-3p, miR-495-3p, miR-543.
Downregulated by Inflammatory Pain: miR-10a-5p, miR-124-3p, miR-134-5p, miR-183-5p, miR-29a-3p, miR-98-5p, miR-99a-5p.
Downregulated by Ischemia-Reperfusion Injury: miR-146a-5p, miR-199a-3p, miR-210-3p.
Regulated by Pain:
Regulated by Contusive Spinal Cord Injury: miR-100-5p, miR-103a-3p, miR-107, miR-124-3p, miR-127-3p, miR-128-3p, miR-133a-3p, miR-133b, miR-154-5p, miR-181a-5p, miR-451a, miR-487b-3p, miR-99a-5p.
Complex Regional Pain Syndrome: miR-106b-5p, miR-126-3p, miR-130b-3p, miR-132-3p, miR-142-5p, miR-155-5p, miR-16-5p, miR-181a-5p, miR-20a-5p, miR-20b-5p, miR-221-3p, miR-25-3p, miR-93-5p.
Responsive to Antiinflammatories: miR-142-3p, miR-146b-5p, miR-203a, miR-208a-3p, miR-21-5p, miR-219a-2-3p, miR-219a-5p, miR-302d-3p.
Responsive to Neuroprotection: miR-199a-3p, miR-210-3p, miR-219a-2-3p, miR-323a-3p, miR-324-5p, miR-331-5p, miR-365b-3p, miR-369-5p, miR-376b-5p, miR-7-5p.
Apoptosis: miR-1, miR-106b-5p, miR-125b-5p, miR-128-3p, miR-133a-3p, miR-133b, miR-134-5p, miR-143-3p, miR-145-5p, miR-146a-5p, miR-15b-5p, miR-16-5p, miR-17-5p, miR-181a-5p, miR-183-5p, miR-199a-3p, miR-203a, miR-206, miR-20a-5p, miR-210-3p, miR-214-3p, miR-21-5p, miR-221-3p, miR-25-3p, miR-29a-3p, miR-30b-5p, miR-30c-5p, miR-30d-5p, miR-31-5p, miR-323a-3p, miR-34a-5p, miR-34c-5p, miR-365b-3p, miR-378a-3p, miR-451a, miR-7-5p, miR-92a-3p, miR-98-5p.
Inflammation: miR-106b-5p, miR-125b-5p, miR-127-3p, miR-128-3p, miR-130b-3p, miR-145-5p, miR-146a-5p, miR-15b-5p, miR-16-5p, miR-17-5p, miR-181a-5p, miR-199a-3p, miR-20a-5p, miR-20b-5p, miR-21-5p, miR-210-3p, miR-23b-3p, miR-29a-3p, miR-30b-5p, miR-30c-5p, miR-30d-5p, miR-323a-3p, miR-34a-5p, miR-34c-5p, miR-365b-3p, miR-543, miR-93-5p, miR-98-5p, miR-99a-5p.
Associated with Neuropathic Pain in Specific Cells:
Amygdala: miR-182-5p, miR-34c-5p.
Dorsal Root Ganglia Nociceptor: miR-103a-3p, miR-133a-3p, miR-134-5p, miR-143-3p, miR-20a-5p, miR-20b-5p, miR-21-5p, miR-7-5p.
Hippocampus: miR-125b-5p, miR-132-5p.
Immune Cells: miR-124-3p, miR-132-5p.
Insular Cortex: miR-133b.
Prefrontal Cortex: miR-181a-5p, miR-223-3p.
Spinal Dorsal Horn: miR-103a-3p, miR-124-3p, miR-134-5p, miR-23b-3p.
Other miRNA Involved in Pain: miR-339-5p, miR-96-5p

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