400-6699-117转1000
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参考报价: | 4800 RMB(人民币) | 型号: | 胰腺癌突变PCR芯片 Pancreatic Cancer Mutation PCR Array |
品牌: | 英拜生物 | 产地: | 上海 |
关注度: | 8 | 信息完整度: | |
样本: | 典型用户: | 暂无 |
400-6699-117转1000
APC: 1 Assay
The most commonly detected APC inactivation mutations are mainly composed of truncation mutations (due to nonsense mutations and frameshift mutations) and point mutations between codons 1250 and 1578.
BRAF: 1 Assay
The most important BRAF mutation in pancreatic cancer leads to increased kinase activity, the p. V600E mutation.
CDKN2A: 3 Assays
The top CDKN2A loss-of-function mutations occur in the consensus ankyrin domain, which leads to inability to form stable complexes with its targets.
CTNNB1: 9 Assays
The most frequently detected CTNNB1/beta-catenin mutations result in abnormal signaling in the WNT signaling pathway. The mutated codons are mainly several serine/threonine residues targeted for phosphorylation by GSK-3beta.
KRAS: 10 Assays
The mutation assays include the most frequently occurring mutations in KRAS codons 12, 13, and 61. Mutations at these positions result in reduced intrinsic GTPase activity and/or cause KRAS to become unresponsive to RasGAP.
NRAS: 2 Assays
The most important NRAS mutations in pancreatic cancer occur at codon 61.
PIK3CA: 3 Assays
The most frequently occurring PIK3CA mutations mainly belong to two classes: gain-of-function kinase domain activating mutations and helical domain mutations that mimic activation by growth factors.
SMAD4: 1 Assay
SMAD4 encodes a member of the Smad family of signal transduction proteins. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.
TP53: 8 Assays
The most frequently detected somatic mutations in TP53 are largely composed of DNA-binding domain mutations which disrupt either DNA binding or protein structure.
胰腺癌突变PCR芯片 Pancreatic Cancer Mutation PCR Array信息由上海英拜生物科技有限公司为您提供,如您想了解更多关于胰腺癌突变PCR芯片 Pancreatic Cancer Mutation PCR Array报价、型号、参数等信息,欢迎来电或留言咨询。
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