Human T-Cell & B-Cell Activation miRNA PCR Array: MIHS-111Z The Human T-Cell & B-Cell Activation miScript miRNA PCR Array profiles the expression of 84 miRNAs involved in the activation and differentiation of T cells and B cells. This array provides scientific researchers with a convenient way to quickly analyze the miRNAs most relevant to specific stages of T cell and B cell development. Hematopoietic stem cells differentiate into lymphoid and myeloid progenitor cells. To develop into T cells, lymphoid progenitor cells migrate to the thymus, where T cell lineage commitment starts with the double negative (CD4-/CD8-) stage. The cells proceed through the double positive (CD4+/CD8+) stage, and end with the single positive stage, generating either naïve CD4+ or naïve CD8+ T cells. During the adaptive immune response, naïve CD8+ T cells interact with antigen and activate, differentiating into effector T cells and potentially memory T cells after antigen clearance, while naïve CD4+ T cells activated by antigen differentiate into helper T cells. B cells mature in the spleen and remain naïve until they encounter antigen. Activated B cells differentiate into plasma B cells or memory B cells, or undergo an intermediate differentiation step and switch antibody classes to become germinal center B cells. T cell and B cell activation involves many sequential steps and the careful timing of cellular signaling pathways. Specific miRNAs play roles in fine-tuning the differentiation and activation of these essential immune cells, and dysregulation of B cell or T cell functions can cause immunodeficiencies or cancer. A set of controls present on each array enables data analysis using the ΔΔCT method of relative quantification, assessment of reverse transcription performance, and assessment of PCR performance. Using SYBR Green-based real-time PCR, the expression of a focused panel of miRNAs involved in T cell and B cell activation can be easily and reliably analyzed with this miScript miRNA PCR Array.
miScript miRNA PCR Arrays are intended for molecular biology applications. This product is not intended for the diagnosis, prevention or treatment of a disease.
96-well, 384-well ( 4 x 96 ), and Rotor-Disc 100 formats are available
 ProductSpeciesTechnologyCat. No.T-Cell & B-Cell Activation PCR ArrayHumanGene ExpressionPAHS-053ZT-Cell & B-Cell Activation PCR ArrayMouseGene ExpressionPAMM-053ZT-Cell & B-Cell Activation PCR ArrayRatGene ExpressionPARN-053Z    

T-Cell Differentiation*:
Double Negative (CD4-/CD8-): let-7d-5p, let-7e-5p, miR-126-3p, miR-128, miR-146b-5p, miR-15a-5p, miR-17-5p, miR-17-3p, miR-181c-5p, miR-191-5p, miR-19a-3p, miR-199a-5p, miR-20a-5p, miR-20b-5p, miR-221-3p, miR-222-3p, miR-223-3p, miR-28-5p, miR-29c-3p, miR-30e-5p, miR-342-3p, miR-423-5p, miR-93-5p, miR-98-5p.
Double Positive (CD4+/CD8+): let-7b-5p, miR-181a-5p, miR-181b-5p, miR-181d, miR-19b-3p.
CD4+ Naïve: miR-132-3p, miR-146a-5p, miR-182-5p, miR-184, miR-25-3p, miR-326, miR-92a-3p.
CD8+ Naïve: let-7a-5p, let-7c, let-7f-5p, let-7g-5p, miR-130b-3p, miR-139-5p, miR-142-3p, miR-150-5p, miR-155-5p, miR-15a-3p, miR-16-5p, miR-26a-5p, miR-26b-5p, miR-29b-3p, miR-30b-5p, miR-30c-5p, miR-30d-5p.
CD8+ Effector: miR-147a, miR-148a-3p, miR-18a-5p, miR-27a-3p, miR-27b-3p.
CD8+ Memory: let-7i-5p, miR-106b-5p, miR-142-5p, miR-15b-5p, miR-17-5p, miR-21-5p, miR-23a-3p, miR-23b-3p, miR-24-3p, miR-29a-3p, miR-31-5p.
B-Cell Differentiation*:
Naïve: let-7a-5p, let-7b-5p, let-7d-5p, let-7g-5p, let-7i-5p, miR-101-3p, miR-132-3p, miR-142-3p, miR-142-5p, miR-150-5p, miR-181c-5p, miR-195-5p, miR-204-5p, miR-214-3p, miR-221-3p, miR-222-3p, miR-223-3p, miR-29b-3p, miR-30e-5p, miR-331-3p, miR-92a-3p.
Germinal Center: miR-106b-5p, miR-130b-3p, miR-132-3p, miR-148a-3p, miR-15a-5p, miR-15b-5p, miR-16-5p, miR-17-5p, miR-17-3p, miR-181a-5p, miR-181b-5p, miR-191-5p, miR-19a-3p, miR-19b-3p, miR-210, miR-23b-3p, miR-25-3p, miR-28-5p, miR-30d-5p, miR-93-5p, miR-98-5p.
Memory: miR-100-5p, miR-125b-5p, miR-145-5p, miR-146a-5p, miR-155-5p, miR-21-5p, miR-23a-3p, miR-24-3p, miR-26a-5p, miR-26b-5p, miR-27a-3p, miR-27b-3p, miR-29a-3p, miR-29c-3p, miR-30b-5p, miR-30c-5p, miR-34a-5p.
Differentially Expressed in Tregs: miR-100-5p, miR-125b-5p, miR-146a-5p, miR-181c-5p, miR-20b-5p, miR-21-5p, miR-31-5p, miR-335-5p, miR-365a-3p, miR-99a-5p.
T-Cell Activation: let-7e-5p, let-7g-5p, let-7i-5p, miR-106b-5p, miR-139-5p, miR-142-5p, miR-146a-5p, miR-146b-5p, miR-155-5p, miR-15a-5p, miR-15a-3p, miR-181a-5p, miR-181c-5p, miR-195-5p, miR-20b-5p, miR-214-3p, miR-223-3p, miR-23a-3p, miR-23b-3p, miR-25-3p, miR-26a-5p, miR-26b-5p, miR-27a-3p, miR-27b-3p, miR-29a-3p, miR-29b-3p, miR-29c-3p, miR-30a-5p, miR-30b-5p, miR-30e-5p, miR-342-3p, miR-346, miR-574-3p, miR-98-5p.

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