MYC靶标基因PCR芯片可用于研究与MYC调控相关的84个基因的表达情况。
The Human MYC Targets RT² Profiler PCR Array profiles the expression of 84 key cancer-related genes controlled by a major oncogenic transcription factor. MYC contains a basic helix-loop-helix DNA-binding domain and a leucine zipper domain for dimerization with its partner MAX, another basic helix-loop-helix transcription factor. The heterodimer binds enhancer box sequences (E-boxes) in promoters and recruits histone acetyltransferases to mostly upregulate the expression of as many as 15% of the genes in the mammalian genome. MYC signaling is primarily responsible for promoting cell growth and proliferation, and its overexpression drives the formation of what is estimated to be 20% of all human cancers, causing about 100,000 US cancer deaths per year. Therefore, disruption of MYC function has recently been identified as an important target for anti-cancer drug development. Analyzing the expression of MYC-responsive genes can help researchers to better understand its normal functions, its role in oncogenesis, and the mechanism of action of anti-MYC agents at the molecular level. Most of the targets of MYC included on this array have been discovered using genome-wide analysis of both gene expression and MYC promoter binding sites via chromatin immunoprecipitation in various cancer cell lines either normally or artificially over-expressing MYC. These MYC targets regulate essential processes such as apoptosis; cell cycle; cell growth, proliferation, and differentiation; DNA repair; epigenetics; metabolism; protein synthesis, degradation and turnover; RNA processing; and signal transduction. MYC, MAX, and other related transcription factors are also represented by the array. A set of controls present on each array enables data analysis using the ΔΔCT method of relative quantification and assessment of reverse transcription performance, genomic DNA contamination, and PCR performance. Using real-time PCR, research studies can easily and reliably analyze the expression of a focused panel of genes responsive to MYC with this array.
MYC & Co-Transcription Factors: E2F1, MAX, MAZ, MYCL1, MYCN, PIAS2.
Up-Regulated by MYC: AIMP2, APEX1, ATF4, BAX, BCAT1, CAD, CBX3, CCNB1, CCND2, CCT5, CDC25A, CDK4, CHEK1, CKS2, CSDA, CSTB, CTSC, DDX10, DKC1, E2F1, EIF4A1, EIF4B, EIF4E, ENO1, EXOSC8, FASN, GNL3, HK2, HNRNPA1, HNRNPA2B1, LTA4H, MAT2A, MGST1, MSH2, MTHFD1, NAP1L1, NBN, NCL, NME1, NOLC1, NPM1, ODC1, PA2G4, PAICS, PCNA, PHB, POLD2, PPAT, PSMG1, PTEN, PYCR1, RPL13, RPL19, RPL23, RPL27A, RPL5, RPS5, SHMT1, SNRPB, SRM, SRSF1, TERT, TOP1, TP53, TPI1, TYMS, UBE2C.
Down-Regulated by MYC: CDKN1B, CDKN2B, CSDE1, ID3, ILK, ITGB1, MYC, PPP2R4, ZFP36L1.
Apoptosis: BAX, CCNB1, GNL3, NPM1, TP53.
Cell Cycle: CCNB1, CCND2, CDC25A, CDK4, CDKN1B, CDKN2B, GNL3, PA2G4, PCNA, TP53.
Cell Growth & Proliferation: CDKN1B, CKS2, NPM1, PA2G4, PCNA, PHB.
Chromatin Modifying & Associated Proteins: CBX3, NAP1L1.
DNA Repair: AIMP2, APEX1, CHEK1, MSH2, NBN, NPM1, PCNA, TERT, TP53.
DNA Replication: PCNA, POLD2, TOP1.
Extracellular Matrix & Cell Adhesion Molecules: ILK, ITGB1.
Metabolism: BCAT1, CAD, ENO1, FASN, GCLC, HK2, LTA4H, MAT2A, MGST1, MTHFD1, NME1, ODC1, PAICS, PDK1, PPAT, PYCR1, SHMT1, SRM, TPI1, TYMS.
Protein Synthesis, Degradation & Turnover: CCT5, CSTB, CTSC, EIF4A1, EIF4B, EIF4E, NCL, NPM1, PSMG1, PYCR1, RPL13, RPL19, RPL23, RPL27A, RPL5, RPS5, UBE2C.
RNA Processing & Binding Factors: CSDE1, DDX10, DDX39B, DKC1, EXOSC8, HNRNPA1, HNRNPA2B1, NOLC1, SNRPB, SRSF1.
Signal Transduction: ILK, NPM1, PDK1, PPP2R4, PTEN.
Transcription Factors & Cofactors: ATF4, CSDA, ID3, MYC, TP53, ZFP36L1.
Tumor Suppressor Genes: MSH2, PHB, TP53.
 

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