The Human Circadian Rhythms RT² Profiler PCR Array profiles the expression of 84 key genes defining and regulating the biological clock. Synchronization, or "entrainment", of the circadian clock occurs via light stimulus of the hypothalamic suprachiasmatic nucleus (SCN) in the brain and via hormone signaling from the SCN in peripheral tissues. Interacting positive and negative circadian gene feedback loops at the transcriptional and post-translational level set up the circadian "oscillator" and insure tight control over transcription factors regulating expression of the appropriate genes required during circadian days or nights. Genes regulated by circadian rhythms are involved in a diverse range of biological processes that affect physiology, metabolism, and behavior. Although the circadian rhythm target genes in its "output" pathways vary widely from tissue to tissue, the transcription factors encoded by central clock and clock-controlled genes are mostly shared across all cell types. Sleeping disorders (such as apnea, insomnia, and desynchronosis) disrupt the timing of the circadian clock, requiring re-entrainment and causing fatigue. Continued disruption of the circadian clock is a source of bodily stress and a risk factor for cancer and cardiovascular disease. Using real-time PCR, research studies can easily and reliably analyze the expression of a focused panel of genes involved in circadian rhythms with this array.
 

ProductSpeciesTechnologyCat. No.Circadian Rhythms PCR ArrayHumanGene ExpressionPAHS-153ZCircadian Rhythms PCR ArrayMouseGene ExpressionPAMM-153ZCircadian Rhythms PCR ArrayRatGene ExpressionPARN-153Z
Circadian Clock: ARNTL (BMAL1), ARNTL2, BHLHE40 (DEC1), BHLHE41, CLOCK, CSNK1E, CRY1, CRY2, NR1D1, NR1D2 (REV-ERB), PER1, PER2, PER3, RORA, TIMELESS.

Casein Kinases: CSNK1A1, CSNK1D, CSNK1E, CSNK2A1, CSNK2A2.

CREB Signaling: AANAT, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CHRNB2, CREB1, CREB3, KCNMA1, HTR7, MAPK1, MAPK14, MAPK3, MAT2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB, PROKR2.

Light Sensing Proteins:
Melatonin Receptors: MTNR1A, MTNR1B.
Opsins: OPN3, OPN4.
Others: CHRNB2, CRX.

Circadian Regulated Transcription Factors: ALAS1, EGR1, EGR3, EPO, ESRRA, HLF, IRF1, MYOD1, NFIL3, NKX2-5, PAX4, POU2F1, RORB, RORC, SMAD4, SP1, SREBF1, STAT5A, TEF, TFAP2A, TGFB1, WEE1, DBP, PPARA.

Other Common Circadian Regulated Genes: CARTPT, CCRN4L, FBXL21, FBXL3, HEBP1, NCOA3, NMS, NPAS2, NR2F6, PPARGC1A, PRF1, PTGDS, SLC9A3.

 

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