骨质疏松症PCR芯片可用于研究与骨质疏松症相关的84个基因的表达情况。
 

ProductSpeciesTechnologyCat. No.Osteoporosis PCR ArrayHumanGene ExpressionPAHS-170ZOsteoporosis PCR ArrayMouseGene ExpressionPAMM-170ZOsteoporosis PCR ArrayRatGene ExpressionPARN-170Z

The Human Osteoporosis RT² Profiler PCR Array profiles the expression of 84 genes involved in pathogenesis of osteoporosis (OP). Advanced age, gender, and immobilization are major risk factors for developing OP, and additional contributing factors include diminished sex steroid production in post-menopausal women. OP is a metabolic disorder of the bones characterized by low bone mineral density (BMD) and increased incidence of fractures due to disruption of bone remodeling - the balance between bone resorption and bone formation. Bone remodeling is conducted by osteoclasts (cells responsible for bone resorption) and by osteoblasts (cells responsible for bone formation). Osteoblasts have a central role in bone metabolism and are responsible for bone matrix synthesis and mineralization, synthesis of growth factors and hormones, and regulation of osteoclastogenesis for bone resorption. In OP, a pathological imbalance in the bone remodeling process is typically linked to a disruptedRANKL/OPG signaling equilibrium wherein elevated RANKL levels favor resorption through osteoclast formation, function, and survival with lowered BMD. Recent evidence also suggests that inflammation plays a significant role in disrupting osteoclast-osteoblast equilibrium, which affects BMD. Enormous research efforts are underway to determine the molecular mechanisms of pathogenesis of OP with the aim of obtaining novel targets for its treatment and prevention as well as the identification of early diagnostic markers. The genes profiled with this array are associated with osteoblast and osteoclast activity including WNT and BMP signaling pathways, ECM and bone matrix remodeling, and cytokines and growth factors currently associated with OP molecular pathogenesis. A set of controls present on each array enables data analysis using the ΔΔCT method of relative quantification and assessment of reverse transcription performance, genomic DNA contamination, and PCR performance. Using real-time PCR, research studies can easily and reliably analyze the expression of a focused panel of genes involved in osteoporosis with this array.
Bone Remodeling & BMP Signaling: ADCY10, ALOX12, ALOX15, ALOX5, ALPL, BGLAP, BMP2, CLCN7, COL1A1, COL1A2, COMT, CRTAP, CTSK, ENPP1, HSD11B1, IGF1, ITGA1, ITGB3, MMP2, MTHFR, NFATC1, NOG, NOS3, P2RX7, PLOD2, RUNX2, SFRP1, SOST, SPARC, SPP1, STAT1, TIMP2, TWIST1, WNT10B, WNT3A.
Calciotropic Hormones & Receptors: AR, CALCA, CALCR, CASR, CYP17A1, CYP19A1, DBP, ESR1, ESR2, ESRRA, NR3C1, PRL, PTH, PTH1R, PTHLH, SHBG, TSHR, VDR.
Cytokines, Growth Factors & Receptors: BMP2, BMP7, CD40, CNR2, FGFR1, FGFR2, GHRH, IGFBP2, IL15, IL6, IL6R, LEPRE1, LRP1, LRP5, LRP6, LTA, LTBP2, MSTN, NPY, TGFB1, TNFAIP3, TNFRSF11A (RANK), TNFRSF11B (OPG), TNFRSF1B, TNFSF11 (RANKL), VEGFA.
Osteoblast Activity & Differentiation: ALPL, BGLAP, BMP2, RUNX2.
RANK/RANKL/OPG Signaling: TNFRSF11A (RANK), TNFRSF11B (OPG), TNFSF11 (RANKL).
WNT/β-catenin Pathway: DKK1, LRP1, LRP5, LRP6, SFRP4, SOST, TWIST1, WNT10B, WNT3A.
Other Genes: ACP5, CA2, LEP, MAB21L2.
 

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