Human Prostate Cancer miRNA PCR Array: MIHS-112Z The Human Prostate Cancer miScript miRNA PCR Array profiles the expression of 84 miRNAs known to alter their expression during prostate cancer progression and development. This array provides cancer researchers with a convenient way to quickly analyze the miRNAs most relevant to prostate cancer. As an adenocarcinoma or glandular cancer, prostate cancer originates from prostate gland cells. Most prostate cancers grow slowly and respond to androgen ablation therapy (androgen-dependent or AD). However, such tumors eventually become refractory to this therapy, and progress into androgen-independent (castration-resistant) prostate cancers. Perineural invasion, where cancer cells adhere to and wrap around nerves, is the predominant method for prostate cancer local invasion, extraprostatic spread, and metastasis. The molecular mechanisms behind these processes are not well understood, but the discovery of aberrantly regulated miRNA in biopsies from various prostate cancers and in circulation suggests a correlation with the progress of carcinogenesis. This array contains differentially regulated miRNAs based on microarray, real-time RT-PCR, and deep sequencing expression profiling studies involving a broad spectrum of prostate cancer clinical samples and cell lines. The profiling results from this array may yield insights into the molecular mechanisms behind the pathogenesis of prostate cancer. A set of controls present on this array enables data analysis using the ΔΔCT method of relative quantification, assessment of reverse transcription performance, and assessment of PCR performance. Using SYBR Green-based real-time PCR, the expression of a focused panel of miRNAs related to prostate cancer can be easily and reliably analyzed with this miScript miRNA PCR Array.
miScript miRNA PCR Arrays are intended for molecular biology applications. This product is not intended for the diagnosis, prevention or treatment of a disease.
96-well, 384-well ( 4 x 96 ), and Rotor-Disc 100 formats are available.    

Prostate Cancer Versus Normal Tissue or Benign Prostatic Hyperplasia:
Up-regulated: let-7b-5p, let-7f-5p, miR-106b-5p, miR-141-3p, miR-148a-3p, miR-15b-5p, miR-181a-5p, miR-182-5p, miR-183-5p, miR-184, miR-194-5p, miR-196a-5p, miR-200c-3p, miR-20a-5p, miR-21-5p, miR-218-5p, miR-25-3p, miR-26a-5p, miR-26b-5p, miR-32-5p, miR-375, miR-425-5p, miR-96-5p.
Down-regulated: let-7a-5p, miR-100-5p, miR-101-3p, miR-125b-5p, miR-126-3p, miR-126-5p, miR-128, miR-133a, miR-143-3p, miR-145-5p, miR-17-3p, miR-181b-5p, miR-203a, miR-205-5p, miR-223-3p, miR-23b-3p, miR-27a-3p, miR-27b-3p, miR-296-5p, miR-29b-3p, miR-31-5p, miR-330-3p, miR-34a-5p, miR-34b-3p, miR-34c-5p, miR-449a, miR-494, miR-7-5p, miR-93-5p.
Regulated: let-7c, miR-125a-5p, miR-16-5p, miR-17-5p//miR-106a-5p, miR-22-3p, miR-221-3p, miR-222-3p, miR-24-3p, miR-92a-3p, miR-99b-5p.
Androgen-Independent (Castration Resistant Prostate Cancer) Versus Dependent Cancers:
Up-regulated: miR-135b-5p, miR-15a-5p, miR-184, miR-21-5p, miR-221-3p, miR-30c-5p, miR-361-5p, miR-455-5p, miR-616-3p.
Down Regulated: miR-100-5p, miR-125b-5p, miR-128, miR-146a-5p, miR-146b-5p, miR-19b-3p, miR-203a, miR-23b-3p, miR-27b-3p, miR-29b-3p, miR-331-3p, miR-365a-3p, miR-99a-5p.
Regulated: let-7c, miR-135a-5p, miR-16-5p, miR-17-5p//miR-106a-5p, miR-222-3p, miR-92a-3p, miR-99b-5p.
Androgen Receptor-Regulated miRNAs:
Up-regulated: miR-148a-3p, miR-15b-5p, miR-20a-5p, miR-20b-5p, miR-21-5p.
Down-regulated: miR-19b-3p, miR-29b-3p, miR-93-5p.
Regulated: miR-16-5p, miR-17-5p//miR-106a-5p
Perineural Invasion:
Up-regulated: miR-15a-5p, miR-181a-5p, miR-195-5p, miR-21-5p, miR-224-5p, miR-26a-5p, miR-30c-5p.
Down regulated: miR-100-5p, miR-125b-5p, miR-126-3p, miR-145-5p, miR-27a-3p, miR-27b-3p.
Regulated: miR-24-3p, miR-99b-5p.
Aggressive Versus Non-aggressive Prostate Cancer:
Up-regulated: miR-9-3p.
Down-regulated: miR-145-5p, miR-221-3p, miR-330-3p, miR-331-3p, miR-34c-5p.
Regulated: miR-16-5p.
Blood, Plasma, and Serum Markers:
Up-regulated: miR-141-3p, miR-200b-3p, miR-21-5p, miR-375, miR-9-3p.
Regulated: miR-221-3p, miR-26a-5p.
miRNAs Predicted to Regulate Prostate Cancer Genes: miR-3163, miR-3662, miR-3666, miR-374b-5p.

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