吕华教授课题组
400-6699-117转1000
 |
吕 华（Lu, Hua） 博 士
|
主要研究方向
1. 发展开环聚合方法，可控制备聚氨基酸和聚酯等功能高分子生物材料
2. 发展蛋白质化学和合成蛋白质-聚氨基酸偶联物
3. 发展蛋白质药物和基于蛋白质的纳米药物
教育经历
2011/07 – 2014/05 博士后，Scripps研究所化学系
2006/08 – 2011/05 博士, 美国伊利诺伊大学香槟分校材料系
2002/09 – 2006/07 学士，北京大学化学与分子工程学院
部分获奖及荣誉
中国化学会青年化学奖（2017）
国家自然科学基金委员会"优秀青年科学基金"（2017）
中组部青年千人计划（2015）
ACS-AkzoNobel Award for Outstanding Graduate Research in Polymer Chemistry（2013）
IUPAC Prize for Young Chemists, Honorable Mention（2012）
Damon Runyon癌症研究基金会博士后奖学金 (2011-2014)
伊利诺伊大学材料系Racheff-Intel Award (Top Winner, 2011)
国家优秀自费留学生奖 (2010)
第34届国际化学奥林匹克竞赛金牌（2002）
近三年代表论文
[1] Yingqin Hou,† Yu Zhou,† Hao Wang, Ruijue Wang, Jingsong Yuan, Yali Hu, Kai Sheng, Juan Feng, Shengtao Yang, and Hua Lu*, "Macrocyclization of Interferon-Poly(α-amino acid) Conjugates Significantly Improves the Tumor Retention, Penetration, and Antitumor Efficacy", J. Am. Chem. Soc. 2018, 140, 1170-1178. (†equal contribution)
[2] Chong Zhang, Jingsong Yuan, Jianhua Lu, Yingqin Hou, Wei Xiong, and Hua Lu*, "From Neutral to Zwitterionic Poly(α-Amino Acid) Nonfouling Surfaces: Effects of Helical Conformation and Anchoring Orientation", Biomaterials, 2018, Accepted.
[3] Chong Zhang, and Hua Lu*, "Efficient Synthesis and Application of Protein-Poly(α-amino acid) Conjugates", Acta Polymerica Sinica, 2018 (1), 21-31. (Invited Review)
[4] Yingqin Hou,† Yaoyi Wang,† Ruijue Wang, Weier Bao, Xiaobo Xi, Yunlong Sun, Shengtao Yang, Wei Wei,* and Hua Lu*, "Harnessing Phosphato-Platinum Bonding Induced Supramolecular Assembly for Systemic Cisplatin Delivery", ACS Appl. Mater. Interfaces, 2017, 9, 17757-17768. (†equal contribution)
[5] Wei Xiong, Xiaohui Fu, Yaoming Wan, Yunlong Sun, Zhibo Li,* and Hua Lu*, "Synthesis and multimodal responsiveness of poly(α-amino acid)s bearing OEGylated azobenzene side-chains", Polym. Chem. 2016, 7, 6375-6382.
[6] Yingqin Hou, † Jingsong Yuan, † Yu Zhou, Jin Yu, and Hua Lu*, "A Concise Approach to Site-Specific Topological Protein-Poly(amino acid) Conjugates Enabled by in Situ -Generated Functionalities", J. Am. Chem. Soc. 2016, 138, 10995-11000. (†equal contribution)
[7] Jingsong Yuan, Yunlong Sun, Jingyu Wang, and Hua Lu*, "Phenyl Trimethylsilyl Sulfide-Mediated Controlled Ring-Opening Polymerization of α-Amino Acid N-Carboxyanhydrides", Biomacromolecules. 2016, 17, 891-896.
[8] Yunlong Sun, Yingqin Hou, Xuhao Zhou, Jingsong Yuan, Jingyu Wang, and Hua Lu*, "Controlled Synthesis and Enzyme-Induced Hydrogelation of Poly(L-phosphotyrosine)s via Ring-Opening Polymerization of α Amino Acid N Carboxyanhydride", ACS Macro Lett. 2015, 4, 1000-1003.
