Targeting the Purinome
Purines are critical cofactors in the enzymatic reactions that create and maintain living organisms. In humans, there are approximately 3,266 proteins that utilize purine cofactors and these proteins constitute the so-called purinome. The human purinome encompasses a wide-ranging functional repertoire and many of these proteins are attractive drug targets. For example, it is estimated that 30% of modern drug discovery projects target protein kinases and that modulators of small G-proteins comprise more than 50% of currently marketed drugs. Given the importance of purine-binding proteins to drug discovery, the following review will discuss the forces that mediate protein:purine recognition, the factors that determine druggability of a protein target, and the process of structure-based drug design. A review of purine recognition in representatives of the various purine-binding protein families, as well as the challenges faced in targeting members of the purinome in drug discovery campaigns will also be given.
- Computer-Aided Calculation of the Local Folding Potential of Target RNA and Its Use for Ribozyme Design
- Shotgun phage display Selection for bacterial receptins or other exported proteins
- Using a Noncovalent Protection Strategy to Enhance Solid-Phase Synthesis
- 昆虫乳酸脱氢酶(LDH)酶联免疫分析
- In Vivo Detection of Free Radicals in Real Time by Low-Frequency Electron Paramagnetic Resonance Spectroscopy
- OXY-SCORE: A Global Index to Improve Evaluation of Oxidative Stress by Combining Pro- and Antioxidant Markers
- 神经元突触前可塑性的结构及分子基础
- 白细胞介素-2(IL-2)生物学活性测定
- Total RNA Isolation from Bacteria
- Isolation of Kupffer Cells from Rats Fed Chronic Ethanol