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化学生物学实验技术>Oligonucleotide Analogs with Dimethylenesulfide, -sulfoxide, and -sulfone Groups Replacing Phosphodiester Linkages
Oligonucleotide Analogs with Dimethylenesulfide, -sulfoxide, and -sulfone Groups Replacing Phosphodiester Linkages
关键词: oligonucleotide analogs来源: 互联网
As demonstrated by this volume, analogs of oligonucleotides retaining the molecular recognition properties of natural oligonucleotides, but having altered physical, chemical, and biological properties are synthetic targets of some interest. Much of the interest comes from the possibility that such analogs might allow the sequence-specific control of the expression of encoded genetic information in vivo using what has come to be known as the “antisense” strategy (1 –5 ).
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