Real Time In Vivo Quantitation of Tumor Angiogenesis
关键词: quantitation tumor angiogenesis来源: 互联网
Animal models are crucial to further our understanding of tumor biology. For many years, observation chambers, implanted in various animal species, have been used for intravital microscopy of tumor microcirculation. As far back as 1943, Algire described the adaptation of the transparent chamber technique to the mouse (1 ). From the introduction of a subsequent paper by Algire et al. (2 ), the following paragraph is quoted: “Recently, in vivo techniques have been developed which make it possible to make microscopic observations of the development of the blood supply of tumor transplants in the mouse. It has also been possible to obtain a quantitative expression of the morphological changes as they occur over a prolonged period� The results presented indicate (i) that the rapid growth of tumor transplants is dependent upon the development of a rich vascular supply, and (ii) that an outstanding characteristics of the tumor cell is its capacity to elicit continuously the growth of new capillaries.”
推荐方法
- Understanding Metastasis Through Integrin Expression
- Clinically Relevant Metastatic Breast Cancer Models to Study Chemosensitivity
- An In Vitro Osteoclast-Forming Assay to Measure Myeloma Cell-Derived Osteoclast-Activating Factors
- MUC1 Expression in Lung Cancer
- Gene Therapy Vectors Harboring AFP Regulatory Sequences: Preparation of an Adenoviral Vector
- Nude Mouse Lung Metastases Models of Osteosarcoma and Ewing s Sarcoma for Evaluating New Therapeutic Strategies
- Diagnostic Markers in Hepatocellular Carcinoma Using Immunohistochemical Techniques
- Cellular Chemosensitivity Assays: An Overview
- Multimodal Nanoparticulate Bioimaging Contrast Agents
- PNAS:真核生物囊泡转运机理新思路