A Tutorial on Mathematical Modeling of Biological Signaling Pathways
Mathematical models have been widely used in the studies of biological signaling pathways. Among these studies, two systems biology approaches have been applied: top-down and bottom-up systems biology. The former approach focuses on X-omics researches involving the measurement of experimental data in a large scale, for example proteomics, metabolomics, or fluxomics and transcriptomics. In contrast, the bottom-up approach studies the interaction of the network components and employs mathematical models to gain some insights about the mechanisms and dynamics of biological systems. This chapter introduces how to use the bottom-up approach to establish mathematical models for cell signaling studies.
- Slice Cultures for Study of Microglia
- Mobilization of Hematopoietic Stem Cells by Depleting Bone Marrow Macrophages
- Focal Cerebral Ischemia
- Effects of Rho Family GTPases on Cell-Cell Adhesion
- Adipose-Derived Stromal Cells: Cytokine Expression and Immune Cell Contaminants
- 划痕实验方法总结:如何解决划痕宽度不一致的问题
- MTT所有问题大汇总
- 细胞组分和细胞器――细胞器分离
- Immobilization of Enzymes on Thermo-Responsive Polymers
- Cell Migration Analyses Within Fibroblast-Derived 3-D Matrices