The management of clone-bearing recipients and neonatal clones is a critical component of successful cloning of mammals by nuclear transfer. The methodology discussed in this chapter is based largely on a double corticosteroid regime to induce parturition and fetal organ maturation in bovine clones. Lung maturation, particularly, is a major factor in clone calf viability. The animal health care involved in maximizing clone survival begins at embryo transfer and continues for the life of that animal.