Application of Recombinant Antibodies in Cancer Patients
As a consequence of the invention of the hybridoma technology by K�hler and Milstein (1 ), many monoclonal antibodies (MAbs) have been evaluated in clinical trials since the early 1980s. Clinical outcomes were generally poor (2 –5 ), with the notable exception of marked tumor responses, including long-term remissions of patients with malignant B-cell lymphoma who were treated with patient-specific antiidiotypic antibodies (6 –8 ). The main factors responsible for these initial shortcomings were related to the immunogenicity of the murine protein, to modulation of targeted antigens, and to the poor ability of these antibodies to sufficiently mediate antibody-dependent effector functions in humans.
- Cultures of Surgical Material from Lung Cancers: A Kinetic Approach
- MUC1 Expression in Lung Cancer
- Economical Protocol for Combined Single-Strand Conformation Polymorphism and Heteroduplex Analysis on a Standard Capillary Elect
- Nude Mouse Lung Metastases Models of Osteosarcoma and Ewing s Sarcoma for Evaluating New Therapeutic Strategies
- Subcloning of Ovarian Cancer Cell Lines
- Isolation of RNA and DNA From Leukocytes and cDNA Synthesis
- Origin and Pathogenesis of B Cell Lymphomas
- Immune System Functional Pathway Analysis Using Single Cell Network Profiling (SCNP): A Novel Tool in Cancer Immunotherapy
- Gene Therapy for Treatment of Brain Tumors (HSV-tKIn Vivo Gene Transfer): A Case Study
- 细胞因子的检测方法