Xenografting Human Colon Cancers
Xenografting of human tumors has been used to produce samples which are enriched for neoplasia and optimal for subsequent molecular analyses. Molecular studies of xenograft tumors generated from both human colon and pancreatic adenocarcinomas have led to the discovery of important genetic alterations underlying these malignancies (e.g., Smad4, Smad2) (1 ,2 ). Moreover, analysis of pancreatic xenografts helped facilitate the discovery of BCRA2 through identification of homozygous deletions ( 3 ). Furthermore, xenografted tumors have facilitated the discovery of distinctive allelic loss patterns in pancreatic and stomach adenocarcinomas (4 ,5 ). Comparative genomic hybridization analysis of xenografted human gastric cancers has demonstrated consistent DNA copy number changes, including both gains and losses of chromosomal regions (6 ).
- Analysis of Loss of Heterozygosity in Circulating DNA
- Epigenetics in Ovarian Cancer
- Solving Problems in Multiplex FISH
- Comparative Genomic Hybridization Technique
- Parental Smoking and Childhood Leukemia
- Utility of Fine-Needle Aspiration Biopsy for Prospective Analysis of Patients Undergoing Therapy for Metastatic Melanoma
- On-Demand Cleavable Linkers for Radioimmunotherapy
- 甲醇酵母系统表达的影响因素
- Molecular Diagnosis of the 5q Deletion in Malignant Myeloid Disorders
- 基因细胞内导入技术