Histopathological Assessment of Metastasis
In spite of advances in the fields of immunohistochemistry and molecular biology, in clinical practice much of the assessment of metastases still relies on light microscopy using conventional histological stains. This is not so much a reflection of a reluctance by histopathologists to adopt new techniques, but more an indication that for most malignancies an enormous amount of useful prognostic data can be gained from relatively unsophisticated assessment of tissues, and that many of the strongest studies of prognostic factors in malignancy predate the era of molecular diagnostics. Although it is undoubtedly true that newer techniques have added prognostic information in the assessment of many tumors, and many, such as the measurement of estrogen receptor status in breast cancer, could be considered routine, a skilled assessment of the morphology of the tissues still provides the fundamental basis of assessing prognosis in the vast majority of cases.
- Assessment of Intestinal Stem Cell Survival Using the Microcolony Formation Assay
- Anti-HMdU Autoantibodies in Human Sera as a Biomarker of Cancer Risk
- Fluorescence In Situ Hybridization Methods and Troubleshooting Applied to Fixed Cell Suspensions
- Xenograft Models in Immunodeficient Animals: I. Nude Mice: Spontaneous and Experimental Metastasis Models
- Recombinant Single-Chain and Disulfide-Stabilized Fv Immunotoxins for Cancer Therapy
- Conversion Technology and Cancer Predispositions
- Application of Silicon Sensor Technologies to Tumor Tissue In Vitro: Detection of Metabolic Correlates of Chemosensitivity
- Polymerase Chain Reaction Detection of DNA Sequence Deletions
- Intercellular Adhesion Molecules (ICAM-1, VCAM-1, and LFA-1) in Adenocarcinoma of Lung: Technical Aspects
- d-Glucaric Acid as a Prospective Tumor Marker