Construction of Mutations in the Adenovirus Early Region 3 (E3) Transcription Units
Coding sequence | |||||
---|---|---|---|---|---|
Ad5 (2) | Ad2 (3) | ||||
E3 protein | start | stop | start | stop | Function |
12.5 K | 27,858 | 28,179 | 27,919 | 28,220 | Unknown |
67K | 28,547 | 28,736 | 28,630 | 28,819 | Unknown |
gp 19 K | 28,735 | 29,215 | 28,812 | 29,289 | Inhibits Ad-specific cytotoxic T-lymphocyte recognition and killing of the virally infected cell by binding MHC class I molecules and inhibiting their transport to the cell surface |
11.6K(ADP) a | 29,491 | 29,770 | 29,468 | 29,771 | Required for efficient cell lysis and release of adenovirus from infected cells (4,5) |
10.4 K (RID α) b | 29,784 | 30,057 | 29,781 | 30,054 | 10.4 K and 14.5 K proteins form a complex that. Prevents TNF cytolysis Clears epidermal growth factor and insulin receptors from the infected cell surface Clears Fas antigen from the infected cell surface (6) |
14.5 K (RIDβ) b | 30,062 | 30,458 | 30,059 | 30,449 | |
14.7 K | 30,453 | 30,837 | 30,444 | 30,828 | Inhibits TNF-mduced apoptosis GTPase binding protein (7) |
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