Rat Genomics Applied to Psychiatric Research
Psychiatric diseases are very debilitating and some of them highly prevalent (e.g., depression or anxiety). The rat remains one model of choice in this discipline to investigate the neural mechanisms underlying normal and pathological traits. Genomic tools are now applied to identify genes involved in psychiatric illnesses and also to provide new biomarkers for diagnostic and prognosis, new targets for treatment and more generally to better understand the functioning of the brain. In this report, we will review rat models, behavioral approaches used to model psychiatry-related traits and the major studies published in the field including genetic mapping of quantitative trait loci (QTL), transcriptomics, proteomics and transgenic models.
- A New, Multiplex, Quantitative Real-Time Polymerase Chain Reaction System for Nucleic Acid Detection and Quantification
- High Resolution MICA Genotyping by Sequence-Based Typing (SBT)
- Methods for Selecting Effective siRNA Sequences by using Statistical and Clustering Techniques
- Static and Kinetic Site-Specific ProteinDNA Photocrosslinking: Analysis of Bacterial Transcription Initiation Complexes
- Novel Methodology for Immobilization of Biomolecules on the Surface of a Photoresponsible Polymer Containing Azobenzene Moiety
- Bioinformatic Tools for Identifying Disease Gene and SNP Candidates
- Osmium Tetroxide Modification and the Study of DNA-Protein Interactions
- Transgenic Sheep from Cultured Cells
- Efficient Viral Gene Transfer to Rodent Hearts In Vivo
- Chemistry for Chemical Genomics