Traumatic Brain Injury in Animal Models and Humans
Clinical/behavioral measures have traditionally been used to assess neurologic outcomes after human traumatic brain injury (TBI) as well as in experimental models of TBI. In this chapter, we address the metrics to assess injury/recovery in human TBI and consider the determinants of outcome. Further, we describe the commonly used experimental rodent models of TBI and the behavioral assays employed in these models for three major categories of neurologic assessments: sensorimotor (aggregate and individual tests), cognitive (memory and avoidance paradigms), and affective (novelty, social interaction, and anxiety) behaviors. Finally, we discuss the issues underlying use of behavioral assays in successful translation of candidate therapeutics from experimental models to human TBI.
- Workflow-Based Approaches to Neuroimaging Analysis
- Fabrication and Implementation of Ion-Selective Microelectrodes
- Protein ADP-Ribosylation
- Combining Non-Isotopic Localization of NPY mRNA with Immunocytochemistry
- Purification of Extracted Peptides for Structural Analysis
- Assessing Mechanisms of Glioblastoma Invasion
- High-Speed Videography of Embodied Active Sensing in the Rodent Whisker System
- Mutant Animal Models of Stroke and Gene Expression: The Stroke-Prone Spontaneously Hypertensive Rat
- Role of the Proteasome in Fly Models of Neurodegeneration
- Determination of Monoamine Turnover by Blockade of Their Synthesis or Metabolism