Animal Models of Anxiety and Depression
Animal models of psychiatric conditions such as anxiety and depression attempt to represent some aspect of the etiology, symptomatology, or treatment of these disorders, in order to facilitate their scientific study (Treit, 1994; Mineka, 1985; Marks, 1987; Willner, 1994). Within this broad context, animal models of anxiolytic or antidepressant drug action can be viewed as treatment models concerned with the pharmacological control of human anxiety and depression. Animal models of anxiety, for example, have been particularly useful in the preclmical testing of benzodiazepme-type anxiolytics, in studying the functional relevance of the GABAA -benzodiazepine receptor system, and in characterizing the effects of benzodiazepine antagonists (e.g., Ro 15–1788 [flumazeml]), partial agonists (e.g., CGS 98961, and inverse agonists (e.g., B-CCM). For reviews see Thlebot (1983); La1 and Emmett-Oglesby (1983); File (1984;1985;1987); Crawley (1985); Treit (1985a;1994); Shephard (1986); Gardner (1988); Thiebot et al. (1988); and Lister (1990).
- Acute and Chronic Social Defeat: Stress Protocols and Behavioral Testing
- Microelectrode Designs for Oxidase-Based Biosensors
- Use and Visualization of Neuroanatomical Viral Transneuronal Tracers
- Isolation and Culture of Primary Pericytes from Mouse Brain
- Animal Models of Nicotine Withdrawal: Intracranial Self-Stimulation and Somatic Signs of Withdrawal
- Patch-Clamp Technique in Brain Slices
- Determination of Histamine in Microdialysis Samples from the Rodent Brain by Column Liquid Chromatography
- In Vivo Single Cell Labeling Techniques
- Electrophysiological Assessment of Spinal Cord Function on Rodents Using tcMMEP and SSEP
- Use of Mesenchymal Stem Cells for Gene Delivery to Intracranial Glioma