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In Vivo Methods for Studying Receptors
Identifying receptors associated with complex neuronal processes such as arousal, attention, and pain sensation is dependent on techniques for probing the consequences of transmitter release and receptor activation in vivo.However, over the last 15 yr there has been shift in focus toward studying receptors on CNS neurons maintained in vitro.The development of techniques for maintaming and recording from mammalian neurons in vitro has allowed for an unparalleled growth in understanding the cellular neuropharmacology of receptor action.The ability to control the microenvironment, including the concentration of drugs and neurotransmitters, surrounding neurons in vitro, although maintaining long-lasting recordings from single neurons is simply not possible for in vivo recording.
- In Vivo Microdialysis to Study Striatal Dopaminergic Neurodegeneration
- Species, Strain, and Gender Issues in the Development and Validation of Animal Models of Dementia
- Environmental Modulation of Drug Taking
- Combination of In Vivo Microdialysis with Selective Electrochemical Detection for Online Continuous Monitoring of Brain Chemistr
- Application of the Protein Truncation Test (PTT) for the Detection of Tuberosis Sclerosis Complex Type 1 and 2 (TSC1 andTSC2) Mu
- Characterizing the Pharmacology of G Protein-Coupled Receptors in Transfected Cell Lines
- In Vivo Ca2+ Imaging of the Living Brain Using Multi-cell Bolus Loading Technique
- Dissociating Behavioral, Autonomic, and Neuroendocrine Effects of Androgen Steroids in Animal Models
- Myocardial Ischemia-Reperfusion Injury and Proteolysis of Fodrin, Ankyrin, and Calpastatin
- Viral Vectors in Primate Research: Examples from Parkinsons Disease Research
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