Immunobiology of Neural Xenotransplantation
The field of neural transplantation has rapidly progressed during the past two decades. Since the first published observations on the functional effects of transplanted fetal dopamine (DA) neurons in rodents (Perlow et al., 1979 ; Bj�rklund and Stenevi, 1979 ), there are now several ongoing clinical trials to assess the efficacy of transplanting human fetal neurons for the treatment of patients with Parkinson’s disease (PD) (Freed et al., 1992 ; Widner et al., 1992 ) and Huntington’s disease (HD) (Kopyov et al., 1996 ). However, a major limitation to the widespread clinical application of this approach is the inability to obtain consistently suitable specimens for transplantation, and the ethical concerns of using human fetal tissue. Consequently, the use of donor tissue from other species as xenografts has been proposed as an alternative to the use of human fetal allografts.
- Use of Gel Zymography to Examine Matrix Metalloproteinase (Gelatinase) Expression in Brain Tissue or in Primary Glial Cultures
- The Use of Small Noncoding RNAs to Silence Transcription in Human Cells
- Reduction of Submissive Behavior Model for Antidepressant Drug Testing in Mice
- Neurotoxicity Assessment by Recording Electrical Activity from Neuronal Networks on Microelectrode Array Neurochips
- The Anorectic Phenotype of the anx/anx Mouse Is Related to Hypothalamic Dysfunction
- Methods for the Study of Dopamine Receptors Within Lipid Rafts of Kidney Cells
- Lentiviral Transduction of Cultured Microglia
- Viral Vectors to Study Synaptic Function
- Integration of Measures of Functional and Structural MRI
- 海马神经细胞原代培养物致密中心囊泡的动态成像