CD7分子
CD7 分子 CD7 常用单克隆抗体或代号:3A1,Leu9 主要表达细胞:T,NK,不成熟Mysub[T] 分子质量(kDa)和结构:gp40(IgSF) 功 能:T、NK细胞活化 CD7 Membrane glycoprotein and Fc receptor for IgM Homologous to TCR gamma, Ig kappa Membrane expression early during T ontogeny, before TCR rearrangement, persists until terminal stages of T cell development Lower expression in memory T cells vs. naive T cells Positive staining (normal): mature peripheral T cells (85%), post-thymic T cells (majority), NK cells (majority), some myeloid cells Positive staining (disease): T cell ALL; AML (especially M4/M5), chronic myelogenous leukemia, blasts in transient myeloproliferative disorder Negative expression: B cell ALL, Sezary syndrome, adult T cell leukemia/lymphoma Micro images: extranodal NK/T cell lymphoma, nasal type