B Cell Survival Pathway
Physical interactions between intergrin alpha4beta1 heterodimer expressed on B cells and counter receptors on stroma cells are key mediators of the survival of normal and malignant B cells. Recent data indicate that integrin stimulation increases FBI-1, XIAP, surviving, and CCT4 expression but inhibits Requiem, c-Fos, and caspase 3 and 7 induction.
Contributor: Roger Anderson, PhD
REFERENCES: Astier AL et al. Temporal gene expression profile of human precursor B Leukemia cells induced by adhesion receptor: identification of pathways regulating B-cell survival. Blood. 2003;101:1118-1127
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