TACI and BCMA stimulation of B cell immune responses.
TACI and BCMA signal transduction pathway that enhances cell survival APRIL and BAFF (also called TALL-I and BLyS) are TNF family members that act as ligands for the BCMA and TACI receptors. Both APRIL and BAFF bind to both the BCMA and TACI receptors to activate the humoral immune response, stimulating B cell immunoglobulin production and proliferation. BAFF is found as a membrane bound form in T cells and a soluble form that is released from the cell to stimulate B cell proliferation and differentiation. As members of the TNF receptor gene family, BCMA and TACI interact with TRAF family members to transduce signals downstream to NF-kappaB activation and MAP kinase pathways. Abnormally active BAFF or APRIL signaling may play a role in autoimmune disorders such as lupus.
Contributor: Glenn Croston, PhD
REFERENCES: Gross J et al., Nature 2000 Apr 27;404(6781):995-9, TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease. Marsters SA, Yan M, Pitti RM, Haas PE, Dixit VM, Ashkenazi A., Curr Biol 2000 Jun 29;10(13):785-8, Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI. Shu HB, Johnson H., Proc Natl Acad Sci U S A 2000 Aug 1;97(16):9156-61, B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1. Yu, G. et al., Nat Immunol 2000 Sep;1(3):252-6, APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity.
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