API 33-32724-1986
大鼠为期 4 周的亚慢性吸入毒性研究； API 81-07 加氢脱硫煤油 CAS 64742-81-0； API 81-09 加氢脱硫中间馏分油 CAS 64742-80-9； API 81-10 加氢脱硫中间馏分 CAS 64742-80-9

Four-Week Subchronic Inhalation Toxicity Study in Rats; API 81-07 Hydrodesulfurized Kerosine CAS 64742-81-0; API 81-09 Hydrodesulfurized Middle Distillate CAS 64742-80-9; API 81-10 Hydrodesulfurized Middle Distillate CAS 64742-80-9

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标准号

API 33-32724-1986

发布

1986年

发布单位

API - American Petroleum Institute

当前最新

API 33-32724-1986

 

 

适用范围

INTRODUCTION The study described in this report was conducted in accordance with the standard operating procedures of International Research and Development Corporation (IRDC) and the protocol as approved by the Sponsor. Procedures pertinent to this study are described herein. The experimental design of the subject study was predicated on the results of a previously conducted rang-finding study (IRDC Study NO. 418-023). Briefly@ 20 male and 20 female rats of the same source and strain were evenly divided between one control and three treatment groups. Using methods similar to those described in section IV@ treated rats were exposed for six hours per day on five consecutive days. An exposure concentration of 25 mg/m3 was used for all three test materials. Pharmacotoxic signs and body weight were assessed. Survival was 100% in the range-finding study. No exposure related pharmacotoxic signs or body weight fluctuations were seen in the exposed groups. Based on these results@ the three test materials were each administered at 25 mg/m3.

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