D-dimer is a product of fibrinolysis that is assayed in the blood. It is elevated following intravascular thrombosis, disseminated intravascular coagulation (DIC), and other conditions that can cause fibrin generation. Assay of D-dimer is a useful tool when evaluating patients with possible venous thromboembolism (VTE), the absence of D-dimer being helpful in excluding VTE. Clinical and Laboratory Standards Institute document H95-P - Quantitative D-dimer in exclusion of VTE including a description of the value of clinical determination of the pretest probability of VTE; the proper collection and handling of the specimen; assays used for D-dimer analysis; determination of the threshold for exclusion of VTE; interpretation of test results; and aspects of regulatory and accreditation requirements. The guideline is provided for use by laboratory; manufacturers of D-dimer assays; clinicians who use the D-dimer for VTE exclusion; and for accrediting and regulatory agencies.
CLSI H59-P-2010由US-CLSI 发布于 。
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