This Technical Report describes the steps necessary to use and to analyse two-level fractional factorialdesigns through illustration with six distinct applications of this methodology.NOTE 1 Each of these six illustrations is similar in that resource constraints precluded the possibility of naively runningfull factorial designs. Other commonalities among the six examples are noted [e.g. study objective, two levels for factors,response variable(s), factors affecting the response]. On the other hand, the individual illustrations have some salientfeatures that are distinct.NOTE 2 The examples suggest the spectrum of possibilities both in application area and i