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Cytotoxicity grade 4

Cytotoxicity grade 4, Total:128 items.

In the international standard classification, Cytotoxicity grade 4 involves: Air quality, Occupational safety. Industrial hygiene, Microbiology, Protection against dangerous goods, Laboratory medicine, Water quality, Materials and articles in contact with foodstuffs, Packaging materials and accessories, Paper and board, Analytical chemistry, Veterinary medicine, Farming and forestry, Medical equipment, Sterilization and disinfection, Products of the chemical industry, Dentistry, Medical sciences and health care facilities in general.


Professional Standard - Pharmaceutical Packaging, Cytotoxicity grade 4

Standard Association of Australia (SAA), Cytotoxicity grade 4

  • AS 2567:2002 Laminar flow cytotoxic drug safety cabinets
  • AS 2252.5:2017 Controlled environments, Part 5: Cytotoxic drug safety cabinets (CDSC) — Design, construction, installation, testing and use
  • AS 1807:2021 Separative devices — Biological and cytotoxic drug safety cabinets, clean workstations and pharmaceutical isolators — Methods of test

American Society for Testing and Materials (ASTM), Cytotoxicity grade 4

  • ASTM F895-84(2001) Standard Test Method for Agar Diffusion Cell Culture Screening for Cytotoxicity
  • ASTM F895-11(2016) Standard Test Method for Agar Diffusion Cell Culture Screening for Cytotoxicity
  • ASTM E2526-22 Standard Test Method for Evaluation of Cytotoxicity of Nanoparticulate Materials in Porcine Kidney Cells and Human Hepatocarcinoma Cells
  • ASTM E2526-08 Standard Test Method for Evaluation of Cytotoxicity of Nanoparticulate Materials in Porcine Kidney Cells and Human Hepatocarcinoma Cells
  • ASTM E1482-23 Standard Practice for Use of Gel Filtration Columns for Cytotoxicity Reduction and Neutralization
  • ASTM E1482-12(2017) Standard Practice for Use of Gel Filtration Columns for Cytotoxicity Reduction and Neutralization
  • ASTM E1482-12 Standard Practice for Use of Gel Filtration Columns for Cytotoxicity Reduction and Neutralization

Professional Standard - Commodity Inspection, Cytotoxicity grade 4

  • SN/T 2328-2009 Keratinocyte Test for Acute Toxicity of Cosmetics
  • SN/T 3824-2014 Cosmetics phototoxicity test.Red blood cell assay (photohaemolysis and haemoglobin oxidation)
  • SN/T 2330-2009 Cosmetic Embryo and Developmental Toxicity in Mouse Embryonic Stem Cell Assays

中华人民共和国国家质量监督检验检疫总局、中国国家标准化管理委员会, Cytotoxicity grade 4

Association Francaise de Normalisation, Cytotoxicity grade 4

  • NF EN 16418:2014 Papier et carton - Détermination de l'effet cytotoxique d'extraits aqueux en utilisant une lignée cellulaire d'hépatome possédant des enzymes du métabolisme (cellules HepG2)
  • NF EN 15845:2010 Papier et carton - Détermination de la cytotoxicité des extraits aqueux
  • NF Q03-098*NF EN 15845:2010 Paper and board - Determination of the cytotoxicity of aqueous extracts
  • NF Q03-111*NF EN 16418:2014 Paper and board - Determination of the cytotoxicity of aqueous extracts using a metabolically competent hepatoma cell line (HepG2)
  • NF U47-220:2010 Isolement sur culture cellulaire et identification par immunofluorescence du virus de la septicémie hémorragique virale des poissons
  • NF T90-723*NF ISO 21115:2019 Water quality - Determination of acute toxicity of water samples and chemicals to a fish gill cell line (RTgill-W1)
  • NF ISO 21115:2019 Qualité de l'eau - Détermination de la toxicité aiguë d'échantillons d'eau et de produits chimiques vis-à-vis de la lignée cellulaire de branchies de poissons (RTgill-W1)
  • NF EN ISO 10993-5:2010 Évaluation biologique des dispositifs médicaux - Partie 5 : essais concernant la cytotoxicité in vitro
  • NF S11-820:2012 Contact lens solutions - Evaluation of ocular cytotoxic potentiel of lens solution products.
  • NF S99-501-5*NF EN ISO 10993-5:2010 Biological evaluation of medical devices - Part 5 : tests for in vitro cytotoxicity.
  • NF U47-221:2010 Isolation on cell culture and identification by immunofluorescence of infectious haematopoietic necrosis virus of fish.
  • NF U47-222:2010 Isolation on cell culture and identification by seroneutralization of infectious pancreatic necrosis virus of fish
  • NF S99-505:1994 BIOLOGICAL EVALUATION OF MEDICAL DEVICES. PART 5 : TESTS FOR CYTOTOXICITY : IN VITRO METHODS. (EUROPEAN STANDARD EN 30993-5).
  • NF U47-025:2001 Animal health analysis methods - Detection of antibodies against classical swine fever by virus neutralisation test and immunochemistry on cell cultures (IF or IP).
  • NF T90-335-2*NF EN ISO 21427-2:2009 Water quality - Evaluation of genotoxicity by measurement of the induction of micronuclei - Part 2 : mixed population method using the cell line V79
  • NF EN ISO 21427-2:2009 Qualité de l'eau - Évaluation de la génotoxicité par le mesurage de l'induction de micronoyaux - Partie 2 : méthode de la population mélangée à l'aide de la lignée de cellules V79

European Committee for Standardization (CEN), Cytotoxicity grade 4

  • EN 15845:2010 Paper and board - Determination of the cytotoxicity of aqueous extracts
  • EN 16418:2014 Paper and board - Determination of the cytotoxicity of aqueous extracts using a metabolically competent hepatoma cell line (HepG2)
  • EN ISO 10993-5:2009 Biological evaluation of medical devices - Part 5: Tests for in vitro cytotoxicity (ISO 10993-5:2009)
  • EN ISO 21427-2:2009 Water quality - Evaluation of genotoxicity by measurement of the induction of micronuclei - Part 2: Mixed population method using the cell line V79 (ISO 21427-2:2006)
  • EN ISO 10993-5:1999 Biological Evaluation of Medical Devices - Part 5: Tests for In Vitro Cytotoxicity ISO 10993-5:1999; Supersedes EN 30993-5:1994

Danish Standards Foundation, Cytotoxicity grade 4

  • DS/EN 15845:2010 Paper and board - Determination of the cytotoxicity of aqueous extracts
  • DS/EN 30993-5:1994 Biological evaluation of medical devices-Part 5:Tests for cytotoxicity-in vitro methods
  • DS/EN ISO 21427-2/AC:2009 Water quality - Evaluation of genotoxicity by measurement of the induction of micronuclei - Part 2: Mixed population method using the cell line V79
  • DS/EN ISO 21427-2:2009 Water quality - Evaluation of genotoxicity by measurement of the induction of micronuclei - Part 2: Mixed population method using the cell line V79

Lithuanian Standards Office , Cytotoxicity grade 4

  • LST EN 15845-2010 Paper and board - Determination of the cytotoxicity of aqueous extracts

AENOR, Cytotoxicity grade 4

  • UNE-EN 15845:2010 Paper and board - Determination of the cytotoxicity of aqueous extracts
  • UNE-EN 16418:2014 Paper and board - Determination of the cytotoxicity of aqueous extracts using a metabolically competent hepatoma cell line (HepG2)
  • UNE-EN ISO 10993-5:2009 Biological evaluation of medical devices - Part 5: Tests for in vitro cytotoxicity (ISO 10993-5:2009)

German Institute for Standardization, Cytotoxicity grade 4

  • DIN EN 15845:2010-05 Paper and board - Determination of the cytotoxicity of aqueous extracts; German version EN 15845:2010
  • DIN 12980:2005 Laboratory furniture - Safety cabinets for handling cytotoxic substances
  • DIN EN 16418:2014-07 Paper and board - Determination of the cytotoxicity of aqueous extracts using a metabolically competent hepatoma cell line (HepG2); German version EN 16418:2014
  • DIN EN 16418:2014 Paper and board - Determination of the cytotoxicity of aqueous extracts using a metabolically competent hepatoma cell line (HepG2); German version EN 16418:2014
  • DIN EN ISO 10993-5:2009-10 Biological evaluation of medical devices - Part 5: Tests for in vitro cytotoxicity (ISO 10993-5:2009); German version EN ISO 10993-5:2009
  • DIN EN 15845:2010 Paper and board - Determination of the cytotoxicity of aqueous extracts; German version EN 15845:2010
  • DIN 12980:2017 Laboratory installations - Safety cabinets and glove boxes for cytotoxic substances and other CMR drugs
  • DIN 12980:2016 Laboratory installations - Safety cabinets and glove boxes for cytotoxic substances and other CMR drugs
  • DIN 12980:2017-05 Laboratory installations - Safety cabinets and glove boxes for cytotoxic substances and other CMR drugs / Note: DIN 12980 (2005-06) remains valid alongside this standard until 2017-04-01.
  • DIN EN ISO 21427-2:2009-08 Water quality - Evaluation of genotoxicity by measurement of the induction of micronuclei - Part 2: Mixed population method using the cell line V79 (ISO 21427-2:2006); German version EN ISO 21427-2:2009

Professional Standard - Agriculture, Cytotoxicity grade 4

British Standards Institution (BSI), Cytotoxicity grade 4

  • BS EN 15845:2010 Paper and board - Determination of the cytotoxicity of aqueous extracts
  • BS EN 16418:2014 Paper and board. Determination of the cytotoxicity of aqueous extracts using a metabolically competent hepatoma cell line (HepG2)
  • BS EN ISO 10993-5:1999 Biological evaluation of medical devices - Tests for in vitro cytotoxicity
  • BS ISO 21115:2019 Water quality. Determination of acute toxicity of water samples and chemicals to a fish gill cell line (RTgill-W1)
  • PD ISO/TR 10993-55:2023 Biological evaluation of medical devices. Interlaboratory study on cytotoxicity
  • BS ISO 19007:2018 Nanotechnologies. In vitro MTS assay for measuring the cytotoxic effect of nanoparticles
  • PD ISO/TR 22455:2021 Nanotechnologies. High throughput screening method for nanoparticles toxicity using 3D model cells
  • BS ISO 21427-2:2006 Water quality - Evaluation of genotoxicity by measurement of the induction of micronuclei - Mixed population method using the cell line V79
  • BS EN ISO 10993-5:2009 Biological evaluation of medical devices - Part 5: Tests for in vitro cytotoxicity (ISO 10993-5:2009)
  • BS EN ISO 21427-2:2006 Water quality. Evaluation of genotoxicity by measurement of the induction of micronuclei. Mixed population method using the cell line V79
  • BS EN ISO 21427-2:2009 Water quality. Evaluation of genotoxicity by measurement of the induction of micronuclei. Mixed population method using the cell line V79

RU-GOST R, Cytotoxicity grade 4

  • GOST R 54496-2011 Water. The determination of toxicity with use of green freshwater unicellular algae
  • GOST ISO 10993-5-2011 Medical devices. Biological evaluation of medical devices. Part 5. Tests for in vitro cytotoxicity
  • GOST R ISO 10993.5-1999 Medical devices. Biological evaluation of medical devices. Part 5. Tests for cytotoxicity: in vitro methods
  • GOST R 57467-2017 Chemical disinfectants and antiseptics. Determination of toxicity of tissues treated with antibacterial means, on the model of motile cells (spermatozoids of bull)
  • GOST R 53910-2010 Water. Methods of toxicity determination by growth inhibition of marine unicellular algae Phaeodactylum tricornutum Bohlin and Sceletonema costatum (Greville) Cleve
  • GOST R 55763-2013 Unproductive animals. Method of retrospective diagnostics of feline viral rhinotracheitis via red cell-linked-antigen test (RNGA)

General Administration of Quality Supervision, Inspection and Quarantine of the People‘s Republic of China, Cytotoxicity grade 4

  • GB/T 41915-2022 Nanotechnologies—In vitro MTS assay for measuring the cytotoxic effect of nanoparticles
  • GB/T 14926.63-2001 Laboratory animal--Method for examination of simian t lymphotropic virus type 1(STLV-1)
  • GB/T 16886.5-2017 Biological Evaluation of Medical Devices Part 5: In Vitro Cytotoxicity Tests
  • GB/T 16886.5-2003 Biological evaluation of medical devices--Part 5: Test for in vitro cytotoxicity

Taiwan Provincial Standard of the People's Republic of China, Cytotoxicity grade 4

  • CNS 14393-5-2004 Biological evaluation of medical devices – Part 5:Tests for in vitro cytotoxicity
  • CNS 14393.5-2004 Biological evaluation of medical devices – Part 5:Tests for in vitro cytotoxicity

API - American Petroleum Institute, Cytotoxicity grade 4

Occupational Health Standard of the People's Republic of China, Cytotoxicity grade 4

  • GBZ/T(卫生) 240.13-2011 Procedures and tests for toxicological evaluations of chemicals—Part 13:Mammalian spermatogonium/primary spermatocyte chromosome aberration test
  • GBZ/T 240.13-2011 Procedures and tests for toxicological evaluations of chemicals. Part 13: Mammalian spermatogonium/primary spermatocyte chromosome aberration test

International Organization for Standardization (ISO), Cytotoxicity grade 4

  • ISO 21115:2019 Water quality — Determination of acute toxicity of water samples and chemicals to a fish gill cell line (RTgill-W1)
  • ISO 10993-5:1999 Biological evaluation of medical devices - Part 5: Tests for in vitro cytotoxicity
  • ISO 19007:2018 Nanotechnologies — In vitro MTS assay for measuring the cytotoxic effect of nanoparticles
  • ISO/TS 4988:2022 Nanotechnologies — Toxicity assessment and bioassimilation of manufactured nano-objects in suspension using the unicellular organism Tetrahymena sp.
  • ISO 10993-5:1992 Biological evaluation of medical devices — Part 5: Tests for cytotoxicity: in vitro methods
  • ISO 10993-5:2009 Biological evaluation of medical devices — Part 5: Tests for cytotoxicity: in vitro methods
  • ISO/TR 10993-55:2023 Biological evaluation of medical devices — Part 55: Interlaboratory study on cytotoxicity
  • ISO/TR 22455:2021 Nanotechnologies — High throughput screening method for nanoparticles toxicity using 3D model cells
  • ISO 21427-2:2006 Water quality - Evaluation of genotoxicity by measurement of the induction of micronuclei - Part 2: Mixed population method using the cell line V79

VN-TCVN, Cytotoxicity grade 4

  • TCVN 7391-5-2005 Biological evaluation of medical devices.Part 5: Tests for in vitro cytotoxicity

TH-TISI, Cytotoxicity grade 4

  • TIS 2395.5-2008 Biological evaluation of medical devices.part 5: tests for in vitro cytotoxicity

ZA-SANS, Cytotoxicity grade 4

  • SANS 10993-5:2003 Biological evaluation of medical devices Part 5: Tests for in vitro cytotoxicity

American National Standards Institute (ANSI), Cytotoxicity grade 4

PH-BPS, Cytotoxicity grade 4

  • PNS ISO 19007:2021 Nanotechnologies - In vitro MTS assay for measuring the cytotoxic effect of nanoparticles
  • PNS ISO 10993-5:2021 Biological evaluation of medical devices - Part 5: Tests for in vitro cytotoxicity

Korean Agency for Technology and Standards (KATS), Cytotoxicity grade 4

  • KS P ISO 10993-5:2018 Biological evaluation of medical devices — Part 5: Tests for in vitro cytotoxicity
  • KS I ISO 21427-2:2009 Water quality-Evaluation of genotoxicity by measurement of the induction of micronuclei-Part 2:Mixed population method using the cell line V79
  • KS I ISO 21427-2:2014 Water quality — Evaluation of genotoxicity by measurement of the induction of micronuclei — Part 2: Mixed population method using the cell line V79
  • KS I ISO 21427-2-2014(2019) Water quality — Evaluation of genotoxicity by measurement of the induction of micronuclei — Part 2: Mixed population method using the cell line V79

KR-KS, Cytotoxicity grade 4

  • KS P ISO 10993-5-2018 Biological evaluation of medical devices — Part 5: Tests for in vitro cytotoxicity
  • KS C ISO TR 22455-2023 Nanotechnologies — High throughput screening method for nanoparticles toxicity using 3D model cells

Professional Standard - Public Safety Standards, Cytotoxicity grade 4

Professional Standard - Medicine, Cytotoxicity grade 4

  • YY/T 0870.3-2013 Test for genotoxicity of medical devices.Part 3: In vitro mammalian cell gene mutation test using mouse lymphoma cells
  • YY/T 0127.18-2016 Biological evaluation of medical devices used in dentistry.Part 18:Dentine barrier cytotoxicity test
  • YY/T 0870.4-2014 Test for genotoxicity of medical devices.Part 4:Mammalian bone marrow erythocyte micronucleus test
  • YY/T 0993-2015 Biological evaluation of medical devices.Nanomaterial: In vitro cytotoxicity tests (MTT assay and LDH assay)
  • YY/T 1897-2023 Biological evaluation of nanomedical devices Genotoxicity test In vitro mammalian cell micronucleus test

国家药监局, Cytotoxicity grade 4

  • YY/T 0870.6-2019 Medical device genotoxicity testing Part 6: In vitro mammalian cell micronucleus test
  • YY/T 0870.2-2019 Medical device genotoxicity testing Part 2: In vitro mammalian cell chromosome aberration testing
  • YY/T 0870.3-2019 Test for genotoxicity of medical devices.Part 3: In vitro mammalian cell gene mutation test using mouse lymphoma cells

Canadian Standards Association (CSA), Cytotoxicity grade 4

  • CSA Z316.6-02-2002 Evaluation of Single Use Medical Sharps Containers for Biohazardous and Cytotoxic Waste Second Edition
  • CSA Z316.6-07-2007 Evaluation of single-use and reusable medical sharps containers for biohazardous and cytotoxic waste Third Edition

BE-NBN, Cytotoxicity grade 4

  • NBN-EN 30993-5-1994 Biological evaluation of medical devices - Part 5: Tests for cytotoxicity - in vitro methods (ISO 10993-5:1992)

RO-ASRO, Cytotoxicity grade 4

Shaanxi Provincial Standard of the People's Republic of China, Cytotoxicity grade 4

  • DB/6100 B21 023-1988 Seed quality grading standard of Brassica napus cytoplasmic male sterile "three lines" and its hybrid "Qinyou No.2"




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