The Guardian of Genome: Three Faces of P53 Tumor-Suppressor

commonest in human cancer. The protein controls various cellular processes such as DNA repair and apoptosis, and functions as the guardian against genomic instability. The three types of interactions are shown; sequence-specific DNA binding through the core region (1TUP.pdb, Gorina et al. Science vol. 265, 346), binding with 53BP1 BRCT domains (1GZH.pdb, Derbyshire et al. EMBOJ vol. 21, 3863) and a tetramer of the c-terminal oligomerization domain (1SAE.pdb, Clore et al. NatStrBio vol. 2, 321).