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Bruker Daltonics在ASMS上推出革命性的超高分辨TOF质谱maXis

2008.6.04

2008年6月
丹佛，商业电讯，2008年6月2日，布鲁克道尔顿推出maXis™，革命性的新的电喷雾－超高分辨率串联飞行时间 (UHR-Qq-TOF)质谱仪，新型的maXis 展示了布鲁克在设计尖端质谱方面的领先地位，以满足未来的应用需求，包括：小分子鉴定，代谢组学，定量蛋白质组学，生物标志物的发现及验证。

maXis 可在宽质量范围内，达到40,000 ～ 60,000 FWHM的分辨率，MS和MS/MS质量准确度达600～800 ppb，所有的速度可达到每秒采集20张谱图。在这些无与伦比的性能组合下，maXis 提供：

1）对于高速液相色谱，可在超高质量分辨时达到20 Hz的全谱图采集速度

2）在宽质量范围内，在MS和MS/MS模式下均可获得40,000 ～ 60,000 FWHM的分辨率

3）宽m/z质量范围

4）新型的IonCooler™技术，在宽的m/z范围内，可获得出色的MS/MS灵敏度

5）高达5个数量级的动态范围，适用于复杂混合物的痕量检测

6）在MS和MS/MS模式下，均可获得亚ppm级的质量准确度，用于高确定性的鉴定）

7）用于（目标物）发现应用的超高质谱灵敏度

8）SmartFormula™ 三维高确定性的分子测定，可计算化学式至1,000 Da

“现在，在宽质量范围内获得超高分辨的质谱，最终会兼容超高效液相色谱。” Ian Sanders，布鲁克道尔顿的执行副总裁说，“我们的新maXis的确代表了串联质谱技术的主要进步，对于精确质量测定，宽质量范围内的超高分辨率，在高速下获得MS和MS/MS的高灵敏度，maXis提供了一个出色的解决方案，能利用现代快速液相色谱或快速毛细管电泳分离的所有优点。”

Richard Joyce博士，辉瑞Pfizer公司的结构鉴定科学家评论说：“ 大大省时地解决现实生活中的鉴定问题对我们至关重要：我们在maXis性能的水平上，利用SmartFormula 3D的合作开发，达到了“一杆式分子式机器(one-shot Molecular Formula Machine)”的目标。”

在周日（6月1日）的布鲁克道尔顿的用户会上，一位著名的研究者将详细介绍他的小组使用布鲁克道尔顿的仪器，包括maXia，进行的一系列创新的应用。周一会有一个香槟招待会，介绍新推出的maXis。

英文原文：
Bruker Daltonics Introduces maXis™, a Revolutionary New Ultra-High Resolution TOF Mass Spectrometer at ASMS Conference
. June 2008

DENVER--(BUSINESS WIRE)--June 2, 2008--At ASMS 2008, Bruker Daltonics today announced the maXis™, a revolutionary new Electrospray Ultra-High Resolution tandem TOF (UHR-Qq-TOF) mass spectrometer. The novel maXis demonstrates Bruker's leadership in the design of cutting-edge mass spectrometers to meet future requirements in applications including small molecule identification, metabolomics, quantitative proteomics, as well as biomarker discovery and validation.

The maXis is unique in offering simultaneous no-compromise ultra-high resolution of 40,000 - 60,000 FWHM over a broad mass range, MS and MS/MS mass accuracy typically between 600 and 800 ppb, and all at speeds of up to 20 full spectra per second. With its unprecedented performance combination, the maXis offers:

-- 20 Hz full spectra acquisition at ultra-high mass resolution for high-speed liquid chromatography

-- 40,000 - 60,000 resolution in both MS and MS/MS mode over a broad mass range

-- excellent high m/z mass range

-- novel IonCooler™ technology delivers excellent MS/MS sensitivity over a broad m/z range

-- high dynamic range of 5 orders of magnitude for trace detection in complex mixtures

-- sub-ppm mass accuracy in both MS and MS/MS mode for high confidence IDs

-- uncompromised MS sensitivity for discovery applications

-- SmartFormula™ 3D unambiguous determination of molecular sum formulae for molecules up to 1 kDalton;

"Now ultra-high resolution mass spectrometry over broad mass ranges is finally compatible with ultra performance liquid chromatography," explained Bruker Daltonics Executive Vice President Dr. Ian Sanders. "Our new maXis indeed represents a major step forward in tandem mass spectrometry, offering a no-compromise solution for exceptional accurate mass, ultra-high resolution over a broad mass range and high sensitivity MS and MS/MS analysis at a speed able to take full advantage of modern, fast liquid chromatography or fast capillary electrophoresis separations."

Dr. Richard Joyce, Structural Elucidation Scientist at Pfizer (UK), commented: "It is vital to us to solve real-life identification problems in a dramatically reduced time: our joint development of SmartFormula 3D applied at maXis performance levels meets our goal of a one-shot Molecular Formula Machine."

At the Bruker Daltonics Users Forum on Sunday, June 1st, a prestigious panel of researchers made presentations detailing a series of innovative applications utilizing various Bruker Daltonics instruments, including the maXis. On Monday, June 2nd, at 6:30 p.m. there will also be a special champagne reception in the Bruker Hospitality Suite at the Sheraton Denver Hotel for the introduction of the maxis (no registration required).

For more information on the ASMS conference, please visit www.asms.org

For more information about Bruker Daltonics and Bruker Corporation (NASDAQ: BRKR), please visit www.bdal.com and www.bruker.com.

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tof 飞行时间 asms bruker 布鲁克道尔顿

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