OBJECTIVE: The mouse lymphoma forward mutation assay evaluates a test article's mutagenic potential in a specific locus mutation assay using mammalian cells. The objective of the assay is to determine the ability of a test article to induce forward mutations at the thymidine kinase (TK) locus as assayed by colony growth of L5178Y TK+/- mouse lymphoma cells in the presence of 5-trifluorothymidine (TFT).
PUBL 33-31224-1986由API - American Petroleum Institute 发布于 1986-04-01,并于 2011-02-17 实施。
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