PUBL 37-31151-1990

A Thirteen Week Inhalation Toxicity Study of Commercial Hexane in the Rat and Mouse

PUBL 37-31151-1990 发布历史

INTRODUCTION: This study@ conducted for the American Petroleum Institute@ was designed to assess the toxicity of commercial hexane when administered by whole-body inhalation as a respirable vapor to 60 Fischer 344 rats (IO/sex/group) and 60 B6C3Fl mice (la/sex/group). Twenty rats (la/sex/group) and 20 mice (la/sex/group) were exposed to room air and nitrogen. The test substance was administered for 6 hours per day@ 5 days per week@ for 13 weeks at target concentrations of 0@ 900@ 3@000 and 9@000 parts per million (ppm). Exposures commenced in staggered groups by species beginning on 10 April 1989 for the rats and 11 April 1989 for the mice@ and were completed on 12 July 1989 for the rats and 13 July 1989 for the mice.

PUBL 37-31151-1990由API - American Petroleum Institute 发布于 1990-01-01，并于 2008-06-06 实施。

PUBL 37-31151-1990的历代版本如下：

• 1990年01月01日 PUBL 37-31151-1990

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标准号

PUBL 37-31151-1990

发布日期

1990年01月01日

实施日期

2008年06月06日

废止日期

无

中国标准分类号

/

国际标准分类号

/

发布单位

API - American Petroleum Institute

引用标准

89

适用范围

INTRODUCTION: This study@ conducted for the American Petroleum Institute@ was designed to assess the toxicity of commercial hexane when administered by whole-body inhalation as a respirable vapor to 60 Fischer 344 rats (IO/sex/group) and 60 B6C3Fl mice (la/sex/group). Twenty rats (la/sex/group) and 20 mice (la/sex/group) were exposed to room air and nitrogen. The test substance was administered for 6 hours per day@ 5 days per week@ for 13 weeks at target concentrations of 0@ 900@ 3@000 and 9@000 parts per million (ppm). Exposures commenced in staggered groups by species beginning on 10 April 1989 for the rats and 11 April 1989 for the mice@ and were completed on 12 July 1989 for the rats and 13 July 1989 for the mice.