A UNIFIED APPROACH TO THE USE OF HUMAN CLINICAL AND ANIMAL TOXICOLOGIC DATA; APPLICATION TO THE ESTABLISHMENT OF AMBIENT AIR QUALITY CRITERIA VOLUME IA: EFFECT OF OZONE ON AIRWAY RESISTANCE(RAW) AND FORCED EXPIRATORY VOLUME (FEV 1.0) IN HUMANS
INTRODUCTION As we have stated@ to date@ there has been no systematic attempt to combine data from diverse laboratories which relate changes in pulmonary function to increased exposures to ozone. This is particularly true with regard to the express purpose of constructing dose/effect profiles. Consequently@ the limited dose/effect information which is available is largely derived on single sets of data with limited cross comparison (1@2). This study represents an attempt to combine data from diverse studies for the purpose of deriving dose/effect profiles. It is believed that these profiles can provide a broader quantitative and qualitative insight than is currently available. Given the extensive base of information relating ozone exposure to physiological changes in man and animals we have limited this effort to the results of controlled human exposure studies of short (up to 4-hour) duration. Similarly@ we have chosen to examine only two measures of pulmonary function@ namely: Airway Resistance (Raw) and Forced Expiratory Volume in one second (FEV1.0)@ both of which are measures of dynamic lung function. In the future we will report on other measures of lung function in response to ozone challenge as well as the results of studies relative to subjects with underlying respiratory illness.* *NOTE: Since this draft report was prepared there has been additional data forthcoming which further refines the data addressed herein. These new data and their impact on the analysis in this report will be addressed in a companion volume.