The safety requirements applicable to fuel cycle facilities (i.e. facilities for uranium ore processing and refining@ conversion@ enrichment@ fabrication of fuel (including mixed oxide fuel)@ storage and reprocessing of spent fuel@ associated conditioning and storage of waste@ and facilities for the related research and development) are established in Ref. [1]. The requirements applicable specifically to uranium fuel fabrication facilities are established in Appendix I of Ref. [1]. This Safety Guide provides recommendations on meeting the requirements established in Sections 5?C10 and in Appendix I of Ref. [1].