This Technical Specification (prCEN/TS 15606:2009) specifies a high performance liquid chromatographic (HPLC) method for the determination of acesulfame-K, aspartame, neohesperidine-dihydrochalcone and saccharin in foodstuffs. The method has been fully validated [1] for the dialysis procedure through collaborative trial, according to the IUPAC Harmonised Protocol [2], on the following analyte matrix combinations: acesulfame-K and aspartame in water-based drink, fruit-based drink, cheesecake with biscuit base, canned soup and instant chocolate drink; saccharin in water-based drink, fruit-based drink, cheesecake with biscuit base and canned soup; neohesperidine-dihydrochalcone in water-based drink, fruit-based drink and canned soup.