This Safety Guide covers the preparation of the safety case and supporting safety assessment for all types of radioactive waste that require specialized disposal facilities. The Safety Guide provides guidance and recommendations on all periods in the development of a disposal facility. The emphasis is on the performance of the disposal facility and the assessment of its impact after closure. Other relevant aspects@ such as operational safety and non-radiological risks@ are addressed but are not discussed in detail. Security aspects are also not discussed in detail although recommendations are provided on meeting the requirement for measures to be implemented to ensure an integrated approach to safety measures and nuclear security measures in the disposal of radioactive waste. This Safety Guide also provides some recommendations on the involvement of interested parties@ issues of communication of risk and approaches to decision making@ as these are essential components of the decision making process in which the safety case is used. It also provides guidance and recommendations on the regulatory process.